{"doi":"10.3389/femer.2024.1357806","title":"The role of place-based factors and other social determinants of health on adverse post-sepsis outcomes: a review of the literature","abstract":"Sepsis remains a common and costly disease. With early recognition and guideline-based treatment, more patients are surviving to hospital discharge. Many survivors experience adverse health events in the months following discharge, while others suffer long-term physical and cognitive decline. Social, biological, and environmental factors affect all aspects of the disease process, from what pathogens one is exposed to, how/if disease develops, what avenues are available for treatment, as well as short- and long-term sequelae of survival. Disparities in sepsis care exist at all stages of a patient's clinical course, but increased survivorship has highlighted the extent to which Social Determinants of Health (SDoH) influence post-discharge adverse events. Despite increased interest in the last decade, a nuanced understanding of causal relationships remains elusive. This is due to several factors: the narrow range of social determinants of health (SDoH) variables typically studied, the inconsistent and non-standardized methods of documenting and reporting SDoH, and the inadequate acknowledgment of how social, environmental, and biological factors interact. Lack of clear understanding of how SDoH influence post- discharge outcomes is an obstacle to development and testing of strategies to mitigate their harms. This paper reviews the literature pertaining to the effects of SDoH on post-discharge outcomes in sepsis, highlights gaps therein, and identifies areas of greatest need for improving the quality and impact of future investigations.","journal":"Frontiers in Disaster and Emergency Medicine","year":2024,"id":442010,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1255515,"name":"Adrienne Malik","orcid":"0000-0002-5598-2932","position":1,"is_corresponding":false},{"id":1255928,"name":"Brian D. Haber","orcid":null,"position":2,"is_corresponding":false},{"id":1121955,"name":"Seth R. Glassman","orcid":null,"position":3,"is_corresponding":false},{"id":1255929,"name":"Cassidy A. Bowen","orcid":null,"position":4,"is_corresponding":false},{"id":536720,"name":"Steven J. Korzeniewski","orcid":"0000-0002-8895-6052","position":5,"is_corresponding":false},{"id":1255516,"name":"Samantha Bauer","orcid":"0000-0002-2529-2930","position":6,"is_corresponding":false},{"id":514124,"name":"Robert Sherwin","orcid":null,"position":7,"is_corresponding":false},{"id":331874,"name":"Robert R. Ehrman","orcid":"0000-0001-9730-8471","position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-19T02:01:15.932178Z","pmid":"40165855","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}