{"doi":"10.3389/fcvm.2022.994419","title":"Long-term use of renin-angiotensin-system inhibitors after acute myocardial infarction is not associated with survival benefits: Analysis of data from the Korean acute myocardial infarction registry-national institutes of health registry","abstract":"Introduction Renin-angiotensin-system inhibitors (RASi) have shown survival benefits after acute myocardial infarction (MI), but the role of routine long-term use of RASi remains unclear. Thereby, we explored the therapeutic effects of RASi medication at 1-year follow-up from acute MI. Methods Using the nationwide Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) registry, we included and analyzed 10,822 subjects. Patients were stratified into those taking RASi at 1-year follow-up ( n = 7,696) and those not taking RASi at 1-year follow-up ( n = 3,126). Patients were followed up for 2-years from the 1-year follow-up; 2-year all-cause mortality and cardiac mortality were analyzed as primary and secondary outcomes, respectively. Results The use of RASi at 1-year follow-up was not associated with decreased all-cause mortality (log-rank P = 0.195) or cardiac mortality (log-rank P = 0.337). In multivariate analyses, RASi medication at 1-year follow-up did not reduce all-cause mortality ( P = 0.758) or cardiac mortality ( P = 0.923), while RASi medication at discharge substantially reduced 1-year all-cause and cardiac mortality. Treatment with either an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker at 1-year follow-up did not show survival benefits from 1-year follow-up, respectively. The use of RASi at 1-year follow-up did not show a prognostic interaction between previous history of chronic kidney disease, post-MI acute heart failure, concomitant use of beta-blockers at 1-year follow-up, or 1-year LVEF. Conclusion Acute MI patients taking RASi at 1-year follow-up were not associated with improved 2-year all-cause mortality or cardiac mortality from the 1-year follow-up. This study provides valuable information regarding tailored medication strategy after acute MI. Clinical trial registration [ www.ClinicalTrials.gov ], identifier [KCT0000863].","journal":"Frontiers in Cardiovascular Medicine","year":2022,"id":294678,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":980020,"name":"Han‐Mo Yang","orcid":"0000-0003-4848-0878","position":1,"is_corresponding":false},{"id":980021,"name":"Jeehoon Kang","orcid":"0000-0002-9078-2231","position":2,"is_corresponding":false},{"id":980022,"name":"Jung‐Kyu Han","orcid":"0000-0002-0016-0747","position":3,"is_corresponding":false},{"id":980023,"name":"Kyung Woo Park","orcid":"0000-0003-2432-4432","position":4,"is_corresponding":false},{"id":980024,"name":"Hyun‐Jae Kang","orcid":"0000-0002-3500-1746","position":5,"is_corresponding":false},{"id":297497,"name":"Bon‐Kwon Koo","orcid":"0000-0002-8188-3348","position":6,"is_corresponding":false},{"id":980382,"name":"Ki‐Bae Seung","orcid":null,"position":7,"is_corresponding":false},{"id":786975,"name":"Kwang Soo","orcid":"0000-0003-0980-0429","position":8,"is_corresponding":false},{"id":786971,"name":"In Whan Seong","orcid":"0000-0003-4628-0258","position":9,"is_corresponding":false},{"id":786968,"name":"Seung‐Woon Rha","orcid":"0000-0001-9456-9852","position":10,"is_corresponding":false},{"id":228977,"name":"Myung Ho Jeong","orcid":"0000-0003-4173-1494","position":11,"is_corresponding":false},{"id":786969,"name":"Hyo‐Soo Kim","orcid":"0000-0003-0847-5329","position":12,"is_corresponding":false},{"id":980019,"name":"Chan Soon Park","orcid":"0000-0003-1717-6662","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T00:31:01.450041Z","pmid":"36119742","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}