{"doi":"10.3389/fcvm.2022.879726","title":"Electronic Cigarette Use and the Risk of Cardiovascular Diseases","abstract":"Electronic cigarettes or e-cigarettes are the most frequently used tobacco product among adolescents. Despite the widespread use of e-cigarettes and the known detrimental cardiac consequences of nicotine, the effects of e-cigarettes on the cardiovascular system are not well-known. Several in vitro and in vivo studies delineating the mechanisms of the impact of e-cigarettes on the cardiovascular system have been published. These include mechanisms associated with nicotine or other components of the aerosol or thermal degradation products of e-cigarettes. The increased hyperlipidemia, sympathetic dominance, endothelial dysfunction, DNA damage, and macrophage activation are prominent effects of e-cigarettes. Additionally, oxidative stress and inflammation are unifying mechanisms at many levels of the cardiovascular impairment induced by e-cigarette exposure. This review outlines the contribution of e-cigarettes in the development of cardiovascular diseases and their molecular underpinnings.","journal":"Frontiers in Cardiovascular Medicine","year":2022,"id":235295,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":82,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":361591,"name":"Xuesi M. Shao","orcid":"0000-0002-5165-347X","position":1,"is_corresponding":false},{"id":853881,"name":"Candice J. Lao","orcid":null,"position":2,"is_corresponding":false},{"id":449045,"name":"Kamrul M. Hasan","orcid":"0000-0002-6561-3524","position":3,"is_corresponding":false},{"id":853882,"name":"Juan Carlos Rivera","orcid":null,"position":4,"is_corresponding":false},{"id":682305,"name":"Maria C. Jordan","orcid":"0000-0001-5272-2185","position":5,"is_corresponding":false},{"id":200411,"name":"Valentina Echeverria","orcid":null,"position":6,"is_corresponding":false},{"id":682308,"name":"Kenneth P. Roos","orcid":"0000-0002-2823-5069","position":7,"is_corresponding":false},{"id":853883,"name":"Amiya P. Sinha-Hikim","orcid":null,"position":8,"is_corresponding":false},{"id":449047,"name":"Theodore C. Friedman","orcid":"0000-0001-9555-7626","position":9,"is_corresponding":false},{"id":853880,"name":"Jorge Espinoza-Derout","orcid":null,"position":0,"is_corresponding":true}],"reference_count":206,"raw_metadata":null,"created_at":"2026-07-19T00:21:48.116752Z","pmid":"35463745","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}