{"doi":"10.3389/fcvm.2022.872757","title":"Age-Related Differences for Cardiorespiratory Fitness Improvement in Patients Undergoing Cardiac Rehabilitation","abstract":"Objective We investigated age-related differences for peak oxygen uptake (peak VO 2 ) improvement with exercise training during cardiac rehabilitation (CR). Patients and Methods This was a retrospective cohort study of the Mayo Clinic Rochester CR program including adult patients who attended CR (≥1 session) for any eligible indication between 1999 and 2017 and who had a cardiopulmonary exercise test pre and post CR with VO 2 data (peak respiratory exchange ratio ≥1.0). Younger (20–49 yrs), midlife (50–64 yrs), and older adults (≥65 yrs) were compared using ANOVA for delta and percent change in peak VO 2 ; and percentage of peak VO 2 responders (>0% change). Results 708 patients (age: 60.8 ± 12.1 years; 24% female) met inclusion criteria. Delta and percent change in peak VO 2 was lower for older adults (1.6 ± 3.2 mL.kg.min −1 ; 12 ± 27%) compared with younger (3.7 ± 4.0 mL.kg.min −1 , p < 0.001; 23 ± 28%, p = 0.002) and midlife adults (2.8 ± 3.8 mL.kg.min −1 , p < 0.001; 17 ± 28%, p = 0.04). For midlife, delta change, but not percent change in peak VO 2 was significantly lower ( p = 0.02) compared with younger. Percentage of responders was only different between older and younger (72 vs. 86%; p = 0.008). Sensitivity analyses in non-surgical patients showed similar differences for delta change, and differences in percent change remained significant between older and younger adults (10 ± 20% vs. 16 ± 18%; p = 0.04). Conclusions In CR patients, older adults had lower improvement in cardiorespiratory fitness than younger and midlife adults. While excluding surgical patients reduced age-related differences, older adults still had lower cardiorespiratory fitness improvement during CR. These findings may have implications for individualizing CR programming in aging populations to reduce future cardiovascular risk.","journal":"Frontiers in Cardiovascular Medicine","year":2022,"id":256309,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8733,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":393524,"name":"José R. Medina‐Inojosa","orcid":"0000-0001-8705-0462","position":1,"is_corresponding":false},{"id":905177,"name":"Audry Chacin‐Suarez","orcid":"0000-0002-7873-9345","position":2,"is_corresponding":false},{"id":399837,"name":"Joshua R. Smith","orcid":"0000-0002-3687-6261","position":3,"is_corresponding":false},{"id":479727,"name":"Ray W. Squires","orcid":"0000-0002-4827-7098","position":4,"is_corresponding":false},{"id":307076,"name":"Randal J. Thomas","orcid":"0000-0003-1448-7182","position":5,"is_corresponding":false},{"id":373738,"name":"Bruce D. Johnson","orcid":"0000-0002-6283-783X","position":6,"is_corresponding":false},{"id":393526,"name":"Thomas P. Olson","orcid":"0000-0002-3446-0414","position":7,"is_corresponding":false},{"id":667905,"name":"Amanda R. Bonikowske","orcid":"0000-0001-9317-4330","position":8,"is_corresponding":false},{"id":905176,"name":"Jenna L. Taylor","orcid":"0000-0003-0073-2714","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:21.336200Z","pmid":"35498026","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}