{"doi":"10.3389/fcvm.2022.868521","title":"L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults","abstract":"Cognitive impairment is a prevailing event in hypertensive patients and in frail older adults. Endothelial dysfunction has been shown to underlie both hypertension and cognitive dysfunction. Our hypothesis is that L-Arginine, which is known to ameliorate endothelial dysfunction, could counteract cognitive impairment in a high-risk population of hypertensive frail older adults. We designed a clinical trial to verify the effects of 4-weeks oral supplementation of L-Arginine on global cognitive function of hypertensive frail older patients. The study was successfully completed by 35 frail hypertensive elderly patients assigned to L-Arginine and 37 assigned to placebo. At follow-up, we found a significant difference in the Montreal Cognitive Assessment (MoCA) test score between the L-Arginine treated group and placebo ( p : 0.0178). Moreover, we demonstrated that L-Arginine significantly attenuates Angiotensin II-induced mitochondrial oxidative stress in human endothelial cells. In conclusion, our findings indicate for the first time that oral L-Arginine supplementation significantly improves cognitive impairment in frail hypertensive older adults. Clinical Trial Registration www.ClinicalTrials.gov , identifier: NCT04962841.","journal":"Frontiers in Cardiovascular Medicine","year":2022,"id":252472,"datarank":0.7614717657759158,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.2847636912237238,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.2847636912237238,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":19,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04962841"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":650783,"name":"Antonella Pansini","orcid":null,"position":1,"is_corresponding":false},{"id":490256,"name":"Stanislovas S. Jankauskas","orcid":"0000-0002-0843-5098","position":2,"is_corresponding":false},{"id":640421,"name":"Fahimeh Varzideh","orcid":"0000-0003-2423-0831","position":3,"is_corresponding":false},{"id":363775,"name":"Urna Kansakar","orcid":"0000-0001-5847-0521","position":4,"is_corresponding":false},{"id":334315,"name":"Angela Lombardi","orcid":"0000-0001-5421-9970","position":5,"is_corresponding":false},{"id":238425,"name":"Valentina Trimarco","orcid":"0000-0001-5869-2247","position":6,"is_corresponding":false},{"id":650785,"name":"Salvatore Frullone","orcid":null,"position":7,"is_corresponding":false},{"id":225561,"name":"Gaetano Santulli","orcid":"0000-0001-7231-375X","position":8,"is_corresponding":false},{"id":497601,"name":"Pasquale Mone","orcid":"0000-0001-6267-5845","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-19T00:24:50.819822Z","pmid":"35498050","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}