{"doi":"10.3389/fcvm.2022.829546","title":"Electrophysiologic Conservation of Epicardial Conduction Dynamics After Myocardial Infarction and Natural Heart Regeneration in Newborn Piglets","abstract":"Newborn mammals, including piglets, exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). The electrophysiologic properties of this naturally regenerated myocardium have not been examined. We hypothesized that epicardial conduction is preserved after P1 MI in piglets. Yorkshire-Landrace piglets underwent left anterior descending coronary artery ligation at age P1 ( n = 6) or P7 ( n = 7), After 7 weeks, cardiac magnetic resonance imaging was performed with late gadolinium enhancement for analysis of fibrosis. Epicardial conduction mapping was performed using custom 3D-printed high-resolution mapping arrays. Age- and weight-matched healthy pigs served as controls ( n = 6). At the study endpoint, left ventricular (LV) ejection fraction was similar for controls and P1 pigs (46.4 ± 3.0% vs. 40.3 ± 4.9%, p = 0.132), but significantly depressed for P7 pigs (30.2 ± 6.6%, p < 0.001 vs. control). The percentage of LV myocardial volume consisting of fibrotic scar was 1.0 ± 0.4% in controls, 9.9 ± 4.4% in P1 pigs ( p = 0.002 vs. control), and 17.3 ± 4.6% in P7 pigs ( p < 0.001 vs. control, p = 0.007 vs. P1). Isochrone activation maps and apex activation time were similar between controls and P1 pigs (9.4 ± 1.6 vs. 7.8 ± 0.9 ms, p = 0.649), but significantly prolonged in P7 pigs (21.3 ± 5.1 ms, p < 0.001 vs. control, p < 0.001 vs. P1). Conduction velocity was similar between controls and P1 pigs (1.0 ± 0.2 vs. 1.1 ± 0.4 mm/ms, p = 0.852), but slower in P7 pigs (0.7 ± 0.2 mm/ms, p = 0.129 vs. control, p = 0.052 vs. P1). Overall, our data suggest that epicardial conduction dynamics are conserved in the setting of natural heart regeneration in piglets after P1 MI.","journal":"Frontiers in Cardiovascular Medicine","year":2022,"id":282088,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":586079,"name":"Terrence Pong","orcid":"0000-0003-4382-9890","position":1,"is_corresponding":false},{"id":933623,"name":"Oluwatomisin Obafemi","orcid":"0000-0002-7826-7755","position":2,"is_corresponding":false},{"id":351368,"name":"Haley J. Lucian","orcid":"0000-0001-6834-7295","position":3,"is_corresponding":false},{"id":957717,"name":"Joy Aparicio‐Valenzuela","orcid":"0000-0002-0477-7496","position":4,"is_corresponding":false},{"id":756804,"name":"Nicholas A. Tran","orcid":null,"position":5,"is_corresponding":false},{"id":735941,"name":"Danielle M. Mullis","orcid":"0000-0003-4743-0000","position":6,"is_corresponding":false},{"id":785296,"name":"Stefan Elde","orcid":null,"position":7,"is_corresponding":false},{"id":271800,"name":"Yuko Tada","orcid":"0000-0003-1410-9894","position":8,"is_corresponding":false},{"id":280016,"name":"Sam W. Baker","orcid":null,"position":9,"is_corresponding":false},{"id":958185,"name":"Caroline Y. Wang","orcid":null,"position":10,"is_corresponding":false},{"id":958186,"name":"Kevin Cyr","orcid":null,"position":11,"is_corresponding":false},{"id":351364,"name":"Michael J. Paulsen","orcid":"0000-0003-1730-0678","position":12,"is_corresponding":false},{"id":351373,"name":"Yuanjia Zhu","orcid":"0000-0001-5642-9883","position":13,"is_corresponding":false},{"id":933624,"name":"Anson M. Lee","orcid":"0000-0002-6703-8957","position":14,"is_corresponding":false},{"id":271806,"name":"Y. Joseph Woo","orcid":"0000-0002-2506-492X","position":15,"is_corresponding":false},{"id":351363,"name":"Hanjay Wang","orcid":"0000-0002-2367-5591","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T00:29:15.734856Z","pmid":"35355973","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}