{"doi":"10.3389/fcvm.2021.717073","title":"Association of Post-operative Systolic Blood Pressure Variability With Mortality After Coronary Artery Bypass Grafting","abstract":"<jats:p><jats:bold>Background:</jats:bold> Blood pressure variability (BPV) has long been considered a risk factor for cardiovascular events. We aimed to investigate whether post-operative systolic BPV was associated with early and late all-cause mortality in patients undergoing coronary artery bypass grafting (CABG).</jats:p><jats:p><jats:bold>Methods:</jats:bold> Clinical variables and blood pressure records within the first 24 h in the post-operative intensive care unit stay from 4,509 patients operated on between 2001 and 2012 were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. BPV was measured as the coefficient of the variability of systolic blood pressure, and we compared patients in the highest quartile with patients in the other three quartiles.</jats:p><jats:p><jats:bold>Results:</jats:bold> After full adjustment, patients in the highest quartile of BPV were at a higher risk of intensive care unit mortality (OR = 2.02, 95% CI: 1.11–3.69), 30-day mortality (OR = 1.92, 95% CI: 1.22–3.02), and 90-day mortality (HR = 1.64, 95% CI: 1.19–2.27). For 2,892 patients with a 4-year follow-up, the association between a higher post-operative BPV and the risk of 4-year mortality was not significant (HR = 1.17, 95% CI: 0.96–1.42). The results were supported by the comparison of survival curves and remained generally consistent in the subgroup analyses and sensitivity analyses.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> Our findings demonstrated that in patients undergoing CABG, a higher post-operative BPV was associated with a higher risk of early mortality while the association was not significant for late mortality. Post-operative BPV can support doctors in identifying patients with potential hemodynamic instability and making timely clinical decisions.</jats:p>","journal":"Frontiers in Cardiovascular Medicine","year":2021,"id":613670,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":81304,"name":"Jiantao Chen","orcid":"0000-0002-7214-2257","position":1,"is_corresponding":false},{"id":1581055,"name":"Guangguo Fu","orcid":null,"position":2,"is_corresponding":false},{"id":1136614,"name":"Xiaodong Zhuang","orcid":"0000-0001-6508-8507","position":3,"is_corresponding":false},{"id":1445909,"name":"Jian Hou","orcid":null,"position":4,"is_corresponding":false},{"id":1467930,"name":"Sida Chen","orcid":"0009-0001-6015-3725","position":5,"is_corresponding":false},{"id":1581056,"name":"Suiqing Huang","orcid":null,"position":6,"is_corresponding":false},{"id":473871,"name":"Yuan Yue","orcid":"0000-0002-4673-9105","position":7,"is_corresponding":false},{"id":1581057,"name":"Liqun Shang","orcid":null,"position":8,"is_corresponding":false},{"id":235019,"name":"Keke Wang","orcid":"0000-0002-3574-8735","position":9,"is_corresponding":false},{"id":1581058,"name":"Linhua Lv","orcid":null,"position":10,"is_corresponding":false},{"id":1581059,"name":"Mengya Liang","orcid":null,"position":11,"is_corresponding":false},{"id":1581060,"name":"Zhongkai Wu","orcid":null,"position":12,"is_corresponding":false},{"id":1390764,"name":"Zhuoming Zhou","orcid":"0000-0003-4996-0582","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association of Post-operative Systolic Blood Pressure Variability With Mortality After Coronary Artery Bypass Grafting","abstract":"<jats:p><jats:bold>Background:</jats:bold> Blood pressure variability (BPV) has long been considered a risk factor for cardiovascular events. We aimed to investigate whether post-operative systolic BPV was associated with early and late all-cause mortality in patients undergoing coronary artery bypass grafting (CABG).</jats:p><jats:p><jats:bold>Methods:</jats:bold> Clinical variables and blood pressure records within the first 24 h in the post-operative intensive care unit stay from 4,509 patients operated on between 2001 and 2012 were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. BPV was measured as the coefficient of the variability of systolic blood pressure, and we compared patients in the highest quartile with patients in the other three quartiles.</jats:p><jats:p><jats:bold>Results:</jats:bold> After full adjustment, patients in the highest quartile of BPV were at a higher risk of intensive care unit mortality (OR = 2.02, 95% CI: 1.11–3.69), 30-day mortality (OR = 1.92, 95% CI: 1.22–3.02), and 90-day mortality (HR = 1.64, 95% CI: 1.19–2.27). For 2,892 patients with a 4-year follow-up, the association between a higher post-operative BPV and the risk of 4-year mortality was not significant (HR = 1.17, 95% CI: 0.96–1.42). The results were supported by the comparison of survival curves and remained generally consistent in the subgroup analyses and sensitivity analyses.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> Our findings demonstrated that in patients undergoing CABG, a higher post-operative BPV was associated with a higher risk of early mortality while the association was not significant for late mortality. Post-operative BPV can support doctors in identifying patients with potential hemodynamic instability and making timely clinical decisions.</jats:p>","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34458342","pmcid":"PMC8387866","openalex_id":"https://openalex.org/W3195530984","authors":[],"funders":[],"total_grants":0,"fwci":1.1691,"citation_percentile":0.80197245,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fcvm.2021.717073/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fcvm.2021.717073/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fcvm.2021.717073/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fcvm.2021.717073","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34458342","host_type":"repository"},{"url":"https://doaj.org/article/d91c78e19b4a46c3bbd4c8fdbbb86ce6","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8387866","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8387866","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8387866?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Blood Pressure and Hypertension Studies","Hemodynamic Monitoring and Therapy","Cardiovascular Health and Disease Prevention"],"mesh_terms":[],"keywords":["Medicine","Quartile","Blood pressure","Intensive care unit","Cardiology","Internal medicine","Bypass grafting","Artery","Risk factor","Surgery","Confidence interval","Mortality","Variability","Intensive Care","Coronary Artery Bypass Grafting"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T08:52:45.559805Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}