{"doi":"10.3389/fcvm.2021.649124","title":"Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis","abstract":"Purpose: Chemical corneal injuries carry a high morbidity and commonly lead to visual impairment. Here, we investigate the role of Serp-1, a serine protease inhibitor, in corneal wound healing. Methods: An alkaline-induced corneal injury was induced in 14 mice. Following injury, five mice received daily topical saline application while nine mice received Serp-1 100 μL topically combined with a daily subcutaneous injection of 100 ng/gram body weight of Serp-1. Corneal damage was monitored daily through fluorescein staining and imaging. Cross sectional corneal H&E staining were obtained. CD31 was used as marker for neovascularization. Results: Serp-1 facilitates corneal wound healing by reducing fibrosis and neovascularization while mitigating inflammatory cell infiltration with no noticeable harm related to its application. Conclusions: Serp-1 effectively mitigates inflammation, decreases fibrosis, and reduce neovascularization in a murine model of corneal injury without affecting other organs. Translational Relavence: Our study provides preclinical data for topical application of Serp-1 to treat corneal wounds.","journal":"Frontiers in Cardiovascular Medicine","year":2021,"id":202501,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.969,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":743001,"name":"Owen Guo","orcid":null,"position":1,"is_corresponding":false},{"id":704649,"name":"Dathe Benissan‐Messan","orcid":"0000-0001-9437-4131","position":2,"is_corresponding":false},{"id":743003,"name":"McKinley H. Shawver","orcid":null,"position":3,"is_corresponding":false},{"id":774703,"name":"Peng Chen","orcid":"0000-0001-7522-3813","position":4,"is_corresponding":false},{"id":743004,"name":"Bingchuan Geng","orcid":null,"position":5,"is_corresponding":false},{"id":500562,"name":"Siqi Wei","orcid":"0000-0002-2603-8248","position":6,"is_corresponding":false},{"id":392469,"name":"Jordan R. Yaron","orcid":"0000-0002-4133-474X","position":7,"is_corresponding":false},{"id":747291,"name":"Alexandra Lucas","orcid":"0000-0002-5195-1442","position":8,"is_corresponding":false},{"id":554568,"name":"Hua Zhu","orcid":"0000-0001-7136-7326","position":9,"is_corresponding":false},{"id":743002,"name":"Brent Ju","orcid":null,"position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-18T23:51:10.291262Z","pmid":"34164439","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}