{"doi":"10.3389/fcvm.2021.645786","title":"Plasma Oxylipins: A Potential Risk Assessment Tool in Atherosclerotic Coronary Artery Disease","abstract":"Background: While oxylipins have been linked to coronary artery disease (CAD), little is known about their diagnostic and prognostic potential. Objective: We tested whether plasma concentration of specific oxylipins may discriminate among number of diseased coronary arteries and predict median 5-year outcomes in symptomatic adults. Methods: Using a combination of high-performance liquid chromatography (HPLC) and quantitative tandem mass spectrometry, we conducted a targeted analysis of 39 oxylipins in plasma samples of 23 asymptomatic adults with low CAD risk and 74 symptomatic adults (≥70% stenosis), aged 38–87 from the Greater Portland, Oregon area. Concentrations of 22 oxylipins were above the lower limit of quantification in >98% of adults and were compared, individually and in groups based on precursors and biosynthetic pathways, in symptomatic adults to number of diseased coronary arteries [(1) n = 31; (2) n = 23; (3) n = 20], and outcomes during a median 5-year follow-up (no surgery: n = 7; coronary stent placement: n = 24; coronary artery bypass graft surgery: n = 26; death: n = 7). Results: Plasma levels of six quantified oxylipins decreased with the number of diseased arteries; a panel of five oxylipins diagnosed three diseased arteries with 100% sensitivity and 70% specificity. Concentrations of five oxylipins were lower and one oxylipin was higher with survival; a panel of two oxylipins predicted survival during follow-up with 86% sensitivity and 91% specificity. Conclusions: Quantification of plasma oxylipins may assist in CAD diagnosis and prognosis in combination with standard risk assessment tools.","journal":"Frontiers in Cardiovascular Medicine","year":2021,"id":174328,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9643,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":475152,"name":"Manuel García‐Jaramillo","orcid":"0000-0003-2987-2913","position":1,"is_corresponding":false},{"id":376789,"name":"Gerd Bobe","orcid":"0000-0002-3129-5628","position":2,"is_corresponding":false},{"id":321220,"name":"Armando Alcázar Magaña","orcid":"0000-0002-4731-0247","position":3,"is_corresponding":false},{"id":333516,"name":"Ashish Vaswani","orcid":"0000-0002-7040-6984","position":4,"is_corresponding":false},{"id":293122,"name":"Jessica Minnier","orcid":"0000-0002-3527-2757","position":5,"is_corresponding":false},{"id":105409,"name":"Donald Β. Jump","orcid":"0000-0002-9473-6283","position":6,"is_corresponding":false},{"id":713789,"name":"Diana Rinkevich","orcid":null,"position":7,"is_corresponding":false},{"id":533468,"name":"Nabil J. Alkayed","orcid":"0000-0002-3489-4730","position":8,"is_corresponding":false},{"id":314736,"name":"Claudia S. Maier","orcid":"0000-0003-0743-8956","position":9,"is_corresponding":false},{"id":455061,"name":"Sanjiv Kaul","orcid":"0000-0003-0124-3920","position":10,"is_corresponding":false},{"id":713362,"name":"D. Elizabeth Le","orcid":"0000-0002-8249-6040","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:54.772014Z","pmid":"33969011","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}