{"doi":"10.3389/fcvm.2020.00155","title":"Central Venous Pressure and Clinical Outcomes During Left-Sided Mechanical Support for Acute Myocardial Infarction and Cardiogenic Shock","abstract":"Background: Right ventricular failure (RVF) is associated with increased mortality among patients receiving left ventricular mechanical circulatory support (LV-MCS) for cardiogenic shock and requires prompt recognition and management. Increased central venous pressure (CVP) is an indicator of potential RVF. Objectives: We studied whether elevated CVP during LV-MCS for acute myocardial infarction complicated by cardiogenic shock is associated with higher mortality. Methods: Between January 2014 and June 2019, we analyzed hemodynamic parameters during Impella LV-MCS from 28 centers in the United States participating in the global, prospective catheter-based ventricular assist device (cVAD) study. A total of 132 patients with a documented CVP measurement while on Impella left-sided support for cardiogenic shock were identified. Results: CVP was significantly higher among patients who died in the hospital (14.0 vs 11.7 mmHg, p=0.014), and a CVP >12 identified patients at significantly higher risk for in-hospital mortality (65% vs 45%, p=0.02). CVP remained significantly associated with in-hospital mortality even after adjustment in a multivariable model (adjusted OR 1.10 [95% CI 1.02-1.19] per 1 mmHg increase). LV-MCS suction events were non-significantly more frequent among patients with high versus low CVP (62.11 vs 7.14 events, p=0.067). Conclusion: CVP is a single, readily accessible hemodynamic parameter which predicts a higher rate of short-term mortality and may identify subclinical RVF in patients receiving LV-MCS for cardiogenic shock.","journal":"Frontiers in Cardiovascular Medicine","year":2020,"id":69936,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9699,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230579,"name":"Katherine Thayer","orcid":"0000-0002-0848-5853","position":1,"is_corresponding":false},{"id":230591,"name":"Daniel Burkhoff","orcid":"0000-0003-3995-2466","position":2,"is_corresponding":false},{"id":104009,"name":"Nir Uriel","orcid":"0000-0003-2301-3587","position":3,"is_corresponding":false},{"id":369943,"name":"E. Magnus Ohman","orcid":"0000-0002-6249-4988","position":4,"is_corresponding":false},{"id":230590,"name":"William W. O’Neill","orcid":"0009-0000-5896-728X","position":5,"is_corresponding":false},{"id":230592,"name":"Navin K. Kapur","orcid":"0000-0002-8302-6796","position":6,"is_corresponding":false},{"id":230580,"name":"Evan H. Whitehead","orcid":"0000-0002-4132-2140","position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-18T21:42:48.813846Z","pmid":"33005634","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}