{"doi":"10.3389/fcvm.2017.00053","title":"Impact of a Genetic Risk Score for Coronary Artery Disease on Reducing Cardiovascular Risk: A Pilot Randomized Controlled Study","abstract":"<h4>Purpose</h4>We tested whether providing a genetic risk score (GRS) for coronary artery disease (CAD) would serve as a motivator to improve adherence to risk-reducing strategies.<h4>Methods</h4>We randomized 94 participants with at least moderate risk of CAD to receive standard-of-care with (<i>N</i> = 49) or without (<i>N</i> = 45) their GRS at a subsequent 3-month follow-up visit. Our primary outcome was change in low density lipoprotein cholesterol (LDL-C) between the 3- and 6-month follow-up visits (ΔLDL-C). Secondary outcomes included other CAD risk factors, weight loss, diet, physical activity, risk perceptions, and psychological outcomes. In pre-specified analyses, we examined whether there was a greater motivational effect in participants with a higher GRS.<h4>Results</h4>Sixty-five participants completed the protocol including 30 participants in the GRS arm. We found no change in the primary outcome between participants receiving their GRS and standard-of-care participants (ΔLDL-C: -13 vs. -9 mg/dl). Among participants with a higher GRS, we observed modest effects on weight loss and physical activity. All other secondary outcomes were not significantly different, including anxiety and worry.<h4>Conclusion</h4>Adding GRS to standard-of-care did not change lipids, adherence, or psychological outcomes. Potential modest benefits in weight loss and physical activity for participants with high GRS need to be validated in larger trials.","journal":"Frontiers in Cardiovascular Medicine","year":2017,"id":731,"datarank":0.5926865577872142,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.0,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0374,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2017-08-14","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":7141,"name":"Shirin Zarafshar","orcid":null,"position":1,"is_corresponding":false},{"id":7142,"name":"Aleksandra Pavlovic","orcid":null,"position":2,"is_corresponding":false},{"id":7143,"name":"Benjamin A. Goldstein","orcid":"0000-0001-5261-3632","position":3,"is_corresponding":false},{"id":7144,"name":"Sandra Tsai","orcid":"0000-0002-8257-8177","position":4,"is_corresponding":false},{"id":2443,"name":"Jin Li","orcid":"0000-0001-9339-3349","position":5,"is_corresponding":false},{"id":7145,"name":"Michael V. McConnell","orcid":"0000-0001-8743-0932","position":6,"is_corresponding":false},{"id":1823,"name":"Devin Absher","orcid":"0000-0003-4405-1646","position":7,"is_corresponding":false},{"id":3451,"name":"Euan A. Ashley","orcid":"0000-0001-9418-9577","position":8,"is_corresponding":false},{"id":7146,"name":"Michaela Kiernan","orcid":"0000-0002-8169-2437","position":9,"is_corresponding":false},{"id":148,"name":"John P. A. Ioannidis","orcid":"0000-0003-3118-6859","position":10,"is_corresponding":false},{"id":7147,"name":"Themistocles L. Assimes","orcid":"0000-0003-2349-0009","position":11,"is_corresponding":false},{"id":7148,"name":"Aleksandra Pavlović","orcid":"0000-0002-2946-7718","position":12,"is_corresponding":false},{"id":7140,"name":"Joshua W. Knowles","orcid":"0000-0003-1922-7240","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}