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By integrating mechanistic insights with translational strategies, this work provides a roadmap for harnessing sialidase biology to advance prevention, diagnosis, and treatment paradigms for diverse human diseases, offering therapeutic opportunities at the intersection of basic science and clinical innovation.</jats:p>","journal":"Frontiers in Cellular and Infection Microbiology","year":2026,"id":621940,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1548897,"name":"Yafei Liu","orcid":null,"position":1,"is_corresponding":false},{"id":1606294,"name":"Rentong Zou","orcid":null,"position":2,"is_corresponding":false},{"id":1606295,"name":"Meifeng Li","orcid":null,"position":3,"is_corresponding":false},{"id":1606293,"name":"Rushi Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Decoding sialidase: physiological roles, pathological pathways, and clinical opportunities","abstract":"<jats:p>This review critically examines pathological dysregulation of sialidase across genetic syndromes, infectious pathogens, inflammatory/autoimmune disorders, malignant transformations, and neurodegenerative cascades, revealing molecular mechanisms that bridge physiological homeostasis to disease pathogenesis. The translational potential is emphasized through its emerging utility as a diagnostic biomarker and therapeutic target, with frank discussion of current challenges in clinical translation-including specificity hurdles, delivery systems, and biomarker validation—and future directions for precision medicine applications. By integrating mechanistic insights with translational strategies, this work provides a roadmap for harnessing sialidase biology to advance prevention, diagnosis, and treatment paradigms for diverse human diseases, offering therapeutic opportunities at the intersection of basic science and clinical innovation.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42205480","pmcid":"PMC13201240","openalex_id":"https://openalex.org/W7160945761","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.50278178,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1814721/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1814721/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fcimb.2026.1814721/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fcimb.2026.1814721","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42205480","host_type":"repository"},{"url":"https://doaj.org/article/9e4e9924b2d34ef28ec50194ac57ebda","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13201240/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC13201240","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC13201240?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Glycosylation and Glycoproteins Research","Cancer Research and Treatments","Endoplasmic Reticulum Stress and Disease","Humans","Neuraminidase","Animals","Autoimmune Diseases","Biomarkers","Neoplasms"],"mesh_terms":["Animals","Autoimmune Diseases","Humans","Neoplasms","Neuraminidase","Biomarkers"],"keywords":["Biomarker","Disease","Translational medicine","Translational research","Diagnostic biomarker","Precision medicine","Biomarker discovery","Pathological","Tumor","Sialic acid","Physiological function","Autoimmune diseases","Sialidase","Desialylation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Industry, innovation and infrastructure"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T17:00:07.840653Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}