{"doi":"10.3389/fcimb.2025.1565103","title":"Progress on the mechanism of intestinal microbiota against colorectal cancer","abstract":"<jats:p>The intestinal microbiota plays a crucial role in the occurrence and development of colorectal cancer, and its anti - colorectal cancer mechanism has become a research hotspot. This article comprehensively expounds on the molecular mechanisms of the intestinal microbiota in anti - colorectal cancer, including aspects such as immune regulation, activation of carcinogenic signaling pathways (it should be noted that it is more reasonable to be “inhibition of carcinogenic signaling pathways”), metabolite - mediated effects, and maintenance of intestinal barrier function. At the same time, it explores the roles and potential mechanisms of intervention methods such as probiotic supplementation therapy, immunotherapy, and fecal microbiota transplantation. In addition, it analyzes the impact of the intestinal flora on the therapeutic efficacy of colorectal cancer. The existing research results are summarized, and the future research directions are prospected, with the aim of providing new theoretical bases and treatment ideas for the prevention and treatment of colorectal cancer.</jats:p>","journal":"Frontiers in Cellular and Infection Microbiology","year":2025,"id":619662,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1287581,"name":"Yu Cui","orcid":"0000-0002-1481-9389","position":1,"is_corresponding":false},{"id":1599315,"name":"Zhiyue Guo","orcid":null,"position":2,"is_corresponding":false},{"id":320661,"name":"Bing Han","orcid":"0000-0002-7299-2753","position":3,"is_corresponding":false},{"id":1599316,"name":"Guogang Zhao","orcid":null,"position":4,"is_corresponding":false},{"id":1599314,"name":"Guoqiang Xing","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Progress on the mechanism of intestinal microbiota against colorectal cancer","abstract":"<jats:p>The intestinal microbiota plays a crucial role in the occurrence and development of colorectal cancer, and its anti - colorectal cancer mechanism has become a research hotspot. This article comprehensively expounds on the molecular mechanisms of the intestinal microbiota in anti - colorectal cancer, including aspects such as immune regulation, activation of carcinogenic signaling pathways (it should be noted that it is more reasonable to be “inhibition of carcinogenic signaling pathways”), metabolite - mediated effects, and maintenance of intestinal barrier function. At the same time, it explores the roles and potential mechanisms of intervention methods such as probiotic supplementation therapy, immunotherapy, and fecal microbiota transplantation. In addition, it analyzes the impact of the intestinal flora on the therapeutic efficacy of colorectal cancer. The existing research results are summarized, and the future research directions are prospected, with the aim of providing new theoretical bases and treatment ideas for the prevention and treatment of colorectal cancer.</jats:p>","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40357397","pmcid":"PMC12066583","openalex_id":"https://openalex.org/W4409902354","authors":[],"funders":[],"total_grants":0,"fwci":3.7957,"citation_percentile":0.93767101,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1565103/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1565103/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fcimb.2025.1565103/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fcimb.2025.1565103","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40357397","host_type":"repository"},{"url":"https://doaj.org/article/c41d694bed3548469249f3ea071457e7","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12066583","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12066583","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12066583?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Gut microbiota and health","Clostridium difficile and Clostridium perfringens research","Gastrointestinal motility and disorders"],"mesh_terms":["Gastrointestinal Microbiome","Fecal Microbiota Transplantation","Animals","Humans","Immunotherapy","Colorectal Neoplasms","Signal Transduction","Probiotics"],"keywords":["Mechanism (biology)","Colorectal cancer","Cancer","Medicine","Immunology","Microbiology","Cancer research","Biology","Internal medicine","Mechanism of action","Immune regulation","Study progress","Gut Microbiota"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T07:58:14.679018Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}