{"doi":"10.3389/fcimb.2021.798924","title":"An Integrative Sialomic Analysis Reveals Molecules From Triatoma sordida (Hemiptera: Reduviidae)","abstract":"Triatomines have evolved salivary glands that produce versatile molecules with various biological functions, including those leading their interactions with vertebrate hosts’ hemostatic and immunological systems. Here, using high-throughput transcriptomics and proteomics, we report the first sialome study on the synanthropic triatomine Triatoma sordida . As a result, 57,645,372 reads were assembled into 26,670 coding sequences (CDS). From these, a total of 16,683 were successfully annotated. The sialotranscriptomic profile shows Lipocalin as the most abundant protein family within putative secreted transcripts. Trialysins and Kazal-type protease inhibitors have high transcript levels followed by ubiquitous protein families and enzyme classes. Interestingly, abundant trialysin and Kazal-type members are highlighted in this triatomine sialotranscriptome. Furthermore, we identified 132 proteins in T. sordida salivary gland soluble extract through LC-MS/MS spectrometry. Lipocalins, Hemiptera specific families, CRISP/Antigen-5 and Kazal-type protein inhibitors proteins were identified. Our study provides a comprehensive description of the transcript and protein compositions of the salivary glands of T. sordida . It significantly enhances the information in the Triatominae sialome databanks reported so far, improving the understanding of the vector’s biology, the hematophagous behaviour, and the Triatominae subfamily’s evolution.","journal":"Frontiers in Cellular and Infection Microbiology","year":2022,"id":276256,"datarank":0.4332063360428296,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.10362264944239664,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.10362264944239664,"corpus_percentile":56.95830432428251,"corpus_rank":5565,"citation_count":8,"citer_count":7,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7428,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":946817,"name":"Paula Beatriz Santiago","orcid":null,"position":1,"is_corresponding":false},{"id":946387,"name":"Sébastien Charneau","orcid":"0000-0002-9364-7289","position":2,"is_corresponding":false},{"id":946388,"name":"Samuel Coelho Mandacaru","orcid":"0000-0001-9255-1958","position":3,"is_corresponding":false},{"id":946389,"name":"Izabela Marques Dourado Bastos","orcid":"0000-0002-2785-4255","position":4,"is_corresponding":false},{"id":946390,"name":"Kaio Luís da Silva Bentes","orcid":"0000-0003-2196-1153","position":5,"is_corresponding":false},{"id":946818,"name":"Sofia Marcelino Martins Silva","orcid":null,"position":6,"is_corresponding":false},{"id":946391,"name":"Waldeyr Mendes Cordeiro da Silva","orcid":"0000-0002-8660-6331","position":7,"is_corresponding":false},{"id":946819,"name":"Ionizete Garcia da Silva","orcid":null,"position":8,"is_corresponding":false},{"id":946392,"name":"Marcelo Valle de Sousa","orcid":"0000-0002-2871-4430","position":9,"is_corresponding":false},{"id":366466,"name":"Célia Maria de Almeida Soares","orcid":"0000-0001-5378-9840","position":10,"is_corresponding":false},{"id":286614,"name":"José M. C. Ribeiro","orcid":"0000-0002-9107-0818","position":11,"is_corresponding":false},{"id":946393,"name":"Jaime M. Santana","orcid":"0000-0002-5206-5741","position":12,"is_corresponding":false},{"id":946394,"name":"Carla Nunes de Araújo","orcid":"0000-0002-1788-9745","position":13,"is_corresponding":false},{"id":946816,"name":"Yanna Reis Praça","orcid":null,"position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-19T00:28:26.545826Z","pmid":"35047420","pmcid":"PMC8762107","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}