{"doi":"10.3389/fcimb.2020.586923","title":"The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis","abstract":"For centuries, hydrogen sulfide (H 2 S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H 2 S production, breakdown, and utilization, H 2 S has emerged as an important signaling molecule in a wide range of physiological and pathological processes. Hence, H 2 S is considered a gasotransmitter along with nitric oxide (•NO) and carbon monoxide (CO). Surprisingly, despite having overlapping functions with •NO and CO, the role of host H 2 S in microbial pathogenesis is understudied and represents a gap in our knowledge. Given the numerous reports that followed the discovery of •NO and CO and their respective roles in microbial pathogenesis, we anticipate a rapid increase in studies that further define the importance of H 2 S in microbial pathogenesis, which may lead to new virulence paradigms. Therefore, this review provides an overview of sulfide chemistry, enzymatic production of H 2 S, and the importance of H 2 S in metabolism and immunity in response to microbial pathogens. We then describe our current understanding of the role of host-derived H 2 S in tuberculosis (TB) disease, including its influences on host immunity and bioenergetics, and on Mycobacterium tuberculosis ( Mtb) growth and survival. Finally, this review discusses the utility of H 2 S-donor compounds, inhibitors of H 2 S-producing enzymes, and their potential clinical significance.","journal":"Frontiers in Cellular and Infection Microbiology","year":2020,"id":101124,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":273290,"name":"Joel N. Glasgow","orcid":"0000-0002-2842-7917","position":1,"is_corresponding":false},{"id":496565,"name":"Sajid Nadeem","orcid":null,"position":2,"is_corresponding":false},{"id":273289,"name":"Vineel P. Reddy","orcid":"0000-0001-8605-3143","position":3,"is_corresponding":false},{"id":495514,"name":"Ritesh Rajesh Sevalkar","orcid":"0000-0002-1694-8854","position":4,"is_corresponding":false},{"id":276048,"name":"Jack R. Lancaster","orcid":null,"position":5,"is_corresponding":false},{"id":273298,"name":"Adrie J. C. Steyn","orcid":"0000-0001-9177-8827","position":6,"is_corresponding":false},{"id":273292,"name":"Md. Aejazur Rahman","orcid":"0000-0002-2616-3372","position":0,"is_corresponding":true}],"reference_count":367,"raw_metadata":null,"created_at":"2026-07-18T22:39:38.259162Z","pmid":"33330130","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}