{"doi":"10.3389/fcimb.2019.00437","title":"The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus","abstract":"Group B Streptococcus (GBS) is a common cause of bacterial urinary tract infections (UTI) in susceptible populations, including pregnant women and the elderly; however, the factors that govern GBS persistence and disease severity in this niche are not fully understood. Here, we report that the presence of the fungus Candida albicans, a common urogenital colonizer, can promote GBS UTI. Co-inoculation of GBS with C. albicans increased bacterial adherence to bladder epithelium and promoted GBS colonization in vivo in a C. albicans adhesin-dependent manner. This study demonstrates that fungal colonization of the urogenital tract may be an important determinant of bacterial pathogenesis during UTI.","journal":"Frontiers in Cellular and Infection Microbiology","year":2020,"id":99698,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":491299,"name":"Anissa R. Ramos","orcid":null,"position":1,"is_corresponding":false},{"id":225239,"name":"Kathryn A. Patras","orcid":"0000-0003-2631-8810","position":2,"is_corresponding":false},{"id":490430,"name":"Angelica M. Riestra","orcid":"0000-0002-7856-2607","position":3,"is_corresponding":false},{"id":490431,"name":"Sinead McCabe","orcid":"0009-0005-1910-9780","position":4,"is_corresponding":false},{"id":225262,"name":"Victor Nizet","orcid":"0000-0003-3847-0422","position":5,"is_corresponding":false},{"id":490432,"name":"Alison Coady","orcid":"0000-0003-1871-5576","position":6,"is_corresponding":false},{"id":421544,"name":"Samuel R. Shing","orcid":"0000-0002-0350-7398","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T22:38:09.754371Z","pmid":"31998657","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}