{"doi":"10.3389/fchem.2022.878835","title":"Automated Synthesis of 18F-BCPP-EF {2-tert-Butyl-4-Chloro-5-{6-[2-(2[18F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2H-Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson’s Disease","abstract":"Mitochondrial complex I (MC-I) is an essential component of brain bioenergetics and can be quantified and studied using positron emission tomography (PET). A specific high affinity 18 F radiotracer for MC-I enables monitoring of neurodegenerative disease progression and pathology via PET imaging. To facilitate clinical research studies tracking MC-I activity in Parkinson’s disease and other neurodegenerative diseases, a fully automated synthesis of the recently described 2 -tert -butyl-4-chloro-5-{6-[2-(2[ 18 F]fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2 H -pyridazin-3-one ([ 18 F] BCPP-EF, [ 18 F]1 ) was developed. We report the first automated synthesis [ 18 F]BCPP-EF using a green radiochemistry approach. The radiotracer was synthesized with good radiochemical yield, excellent radiochemical purity, and high molar activity.","journal":"Frontiers in Chemistry","year":2022,"id":284869,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9556,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":350841,"name":"Allen F. Brooks","orcid":"0000-0003-3773-3024","position":1,"is_corresponding":false},{"id":963546,"name":"Katherine M. Liddell","orcid":null,"position":2,"is_corresponding":false},{"id":352215,"name":"Bradford D. Henderson","orcid":null,"position":3,"is_corresponding":false},{"id":963067,"name":"Brian G. Hockley","orcid":"0000-0003-4112-4299","position":4,"is_corresponding":false},{"id":376246,"name":"Kelvin L. Chou","orcid":"0000-0002-2597-7315","position":5,"is_corresponding":false},{"id":301406,"name":"Roger L. Albin","orcid":"0000-0002-0629-608X","position":6,"is_corresponding":false},{"id":342700,"name":"Peter J. H. Scott","orcid":"0000-0002-6505-0450","position":7,"is_corresponding":false},{"id":754719,"name":"Tanpreet Kaur","orcid":"0000-0002-4700-3116","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:29:40.826853Z","pmid":"35433631","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}