{"doi":"10.3389/fchem.2021.739791","title":"Self-Assembly Dipeptide Hydrogel: The Structures and Properties","abstract":"<jats:p>Self-assembly peptide-based hydrogels are well known and popular in biomedical applications due to the fact that they are readily controllable and have biocompatibility properties. A dipeptide is the shortest self-assembling motif of peptides. Due to its small size and simple synthesis method, dipeptide can provide a simple and easy-to-use method to study the mechanism of peptides’ self-assembly. This review describes the design and structures of self-assembly linear dipeptide hydrogels. The strategies for preparing the new generation of linear dipeptide hydrogels can be divided into three categories based on the modification site of dipeptide: 1) COOH-terminal and N-terminal modified dipeptide, 2) C-terminal modified dipeptide, and 3) uncapped dipeptide. With a deeper understanding of the relationship between the structures and properties of dipeptides, we believe that dipeptide hydrogels have great potential application in preparing minimal biocompatible materials.</jats:p>","journal":"Frontiers in Chemistry","year":2021,"id":44723,"datarank":1.4673908592044902,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"self_citation_contribution":0.5897738449086489,"citation_network_contribution":0.8776170142958414,"self_endowment_contribution":0.5897738449086489,"citer_contribution":0.8776170142958414,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":48,"citers_with_citation_signal":41,"citers_with_endowment":41,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":153,"name":"Li Xie","orcid":"0000-0003-3658-2535","position":1,"is_corresponding":false},{"id":210082,"name":"Renlin Zheng","orcid":null,"position":2,"is_corresponding":false},{"id":210084,"name":"Rongqin Sun","orcid":null,"position":3,"is_corresponding":false},{"id":210080,"name":"Liangchun Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34540806","pmcid":"PMC8440803","openalex_id":"https://openalex.org/W3198691471","authors":[],"funders":[],"total_grants":0,"fwci":2.7396,"citation_percentile":0.90521299,"influential_citations":0,"citation_trend":[{"year":2022,"count":10},{"year":2023,"count":10},{"year":2024,"count":14},{"year":2025,"count":10},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.3389/fchem.2021.739791","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fchem.2021.739791/pdf","host_type":"GOLD"},{"url":"https://doi.org/10.3389/fchem.2021.739791","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fchem.2021.739791/full","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34540806","host_type":"repository"},{"url":"https://doaj.org/article/0d9632f013bd432ebeb5276619d3b909","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC8440803","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8440803","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8440803","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8440803?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Supramolecular Self-Assembly in Materials","Polydiacetylene-based materials and applications","Chemical Synthesis and Analysis","Medicine","Materials Science"],"mesh_terms":[],"keywords":["Dipeptide","Self-healing hydrogels","Biocompatibility","Peptide","Self-assembly","Chemistry","Nanotechnology","Combinatorial chemistry","Materials science","Organic chemistry","Biochemistry","hydrogel","Biocompatible","Ultrashort Peptide"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-01T19:01:04.268119Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}