{"doi":"10.3389/fchem.2020.00441","title":"Dimeric γ-AApeptides With Potent and Selective Antibacterial Activity","abstract":"Over the past few decades, the emergence of antibiotic resistance developed by life-threatening bacteria has become increasingly prevalent. Thus, there is an urgent demand to develop novel antibiotics capable of mitigating this trend. Herein we reported a series of dimeric γ-AApeptide derivatives as potential antibiotic agents with limited toxicity and excellent selectivity against Gram-positive strains. Among them, compound 2 was identified to have the best MICs without inducing drug resistance even after exposure to MRSA for 20 passages. Time-kill kinetics and mechanistic studies suggested that 2 could mimic host-defense peptides (HDPs) and rapidly eradicate MRSA within 2 hours through disturbing the bacteria membrane. Meanwhile, biofilm formation was successfully inhibited even at a low concentration. Taken together, these results suggested the great potential of dimeric γ-AApeptide derivatives as antibacterial agents.","journal":"Frontiers in Chemistry","year":2020,"id":85213,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9457,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":261770,"name":"Ruixuan Gao","orcid":"0000-0001-7137-2512","position":1,"is_corresponding":false},{"id":300808,"name":"Peng Sang","orcid":"0000-0002-8336-4533","position":2,"is_corresponding":false},{"id":300812,"name":"Timothy Odom","orcid":"0000-0003-1599-6245","position":3,"is_corresponding":false},{"id":436987,"name":"Mengmeng Zheng","orcid":null,"position":4,"is_corresponding":false},{"id":300809,"name":"Yan Shi","orcid":"0000-0002-4086-6103","position":5,"is_corresponding":false},{"id":436095,"name":"Hai Xu","orcid":"0000-0003-1610-9556","position":6,"is_corresponding":false},{"id":436096,"name":"Chuanhai Cao","orcid":"0000-0002-5765-6401","position":7,"is_corresponding":false},{"id":300813,"name":"Jianfeng Cai","orcid":"0000-0003-3106-3306","position":8,"is_corresponding":false},{"id":107089,"name":"Minghui Wang","orcid":"0000-0001-9171-4962","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:56:02.794896Z","pmid":"32596202","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}