{"doi":"10.3389/fcell.2026.1698015","title":"H19 and IGF2 imprinting from embryogenesis to oncogenesis","abstract":"<jats:p>\n                    The imprinted\n                    <jats:italic>H19</jats:italic>\n                    /\n                    <jats:italic>IGF2</jats:italic>\n                    locus is critical for fetal development and, when dysregulated, contributes to tumorigenesis. This review examines the mechanisms regulating imprinting through DNA methyltransferases, alongside shared signaling pathways, such as PI3K/AKT, that operate across both embryonic development and tumorigenesis. Parent-of-origin methylation at this locus coordinates differential gene activity:\n                    <jats:italic>IGF2</jats:italic>\n                    promotes organogenesis and placental angiogenesis through mitogenic signaling, while\n                    <jats:italic>H19</jats:italic>\n                    , a long non-coding RNA that serves as a precursor for miR-675-5p, prevents fetal overgrowth, regulates trophoblast invasion, and modulates epithelial-to-mesenchymal transitions (EMT). Loss of imprinting (LOI) at this locus disrupts normal gene expression, contributing to the development of cancer and imprinting disorders. Overexpression of\n                    <jats:italic>H19</jats:italic>\n                    activates the PI3K/AKT pathway and silences tumor suppressor genes such as\n                    <jats:italic>let-7b</jats:italic>\n                    through sponging target genes and subsequently inducing EMT. While LOI of\n                    <jats:italic>IGF2</jats:italic>\n                    leads to cancer through upregulation of the\n                    <jats:italic>Wnt3</jats:italic>\n                    pathway. ​​\n                    <jats:italic>H19</jats:italic>\n                    and\n                    <jats:italic>IGF2</jats:italic>\n                    play opposing yet coordinated roles in embryogenesis, with\n                    <jats:italic>IGF2</jats:italic>\n                    promoting proliferation and\n                    <jats:italic>H19</jats:italic>\n                    restricting overgrowth, a balance essential for proper tissue development. When epigenetically disrupted, it enables tumors to reactivate developmental pathways that drive unchecked growth, EMT, metastasis, and resistance to apoptosis. Controlling the balance of imprinting of the\n                    <jats:italic>H19</jats:italic>\n                    /\n                    <jats:italic>IGF2</jats:italic>\n                    locus presents a promising mechanism for future therapies.\n                  </jats:p>","journal":"Frontiers in Cell and Developmental Biology","year":2026,"id":644303,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1676905,"name":"Rida Saeed","orcid":null,"position":1,"is_corresponding":false},{"id":1676906,"name":"Sloan White","orcid":null,"position":2,"is_corresponding":false},{"id":1676907,"name":"Patrick Tajanlangit","orcid":null,"position":3,"is_corresponding":false},{"id":715596,"name":"G. Ian Gallicano","orcid":"0000-0001-8399-1556","position":4,"is_corresponding":false},{"id":1676904,"name":"Bella Ortega","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"H19 and IGF2 imprinting from embryogenesis to oncogenesis","abstract":"<jats:p>\n                    The imprinted\n                    <jats:italic>H19</jats:italic>\n                    /\n                    <jats:italic>IGF2</jats:italic>\n                    locus is critical for fetal development and, when dysregulated, contributes to tumorigenesis. This review examines the mechanisms regulating imprinting through DNA methyltransferases, alongside shared signaling pathways, such as PI3K/AKT, that operate across both embryonic development and tumorigenesis. Parent-of-origin methylation at this locus coordinates differential gene activity:\n                    <jats:italic>IGF2</jats:italic>\n                    promotes organogenesis and placental angiogenesis through mitogenic signaling, while\n                    <jats:italic>H19</jats:italic>\n                    , a long non-coding RNA that serves as a precursor for miR-675-5p, prevents fetal overgrowth, regulates trophoblast invasion, and modulates epithelial-to-mesenchymal transitions (EMT). Loss of imprinting (LOI) at this locus disrupts normal gene expression, contributing to the development of cancer and imprinting disorders. Overexpression of\n                    <jats:italic>H19</jats:italic>\n                    activates the PI3K/AKT pathway and silences tumor suppressor genes such as\n                    <jats:italic>let-7b</jats:italic>\n                    through sponging target genes and subsequently inducing EMT. While LOI of\n                    <jats:italic>IGF2</jats:italic>\n                    leads to cancer through upregulation of the\n                    <jats:italic>Wnt3</jats:italic>\n                    pathway. ​​\n                    <jats:italic>H19</jats:italic>\n                    and\n                    <jats:italic>IGF2</jats:italic>\n                    play opposing yet coordinated roles in embryogenesis, with\n                    <jats:italic>IGF2</jats:italic>\n                    promoting proliferation and\n                    <jats:italic>H19</jats:italic>\n                    restricting overgrowth, a balance essential for proper tissue development. When epigenetically disrupted, it enables tumors to reactivate developmental pathways that drive unchecked growth, EMT, metastasis, and resistance to apoptosis. Controlling the balance of imprinting of the\n                    <jats:italic>H19</jats:italic>\n                    /\n                    <jats:italic>IGF2</jats:italic>\n                    locus presents a promising mechanism for future therapies.\n                  </jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41890909","pmcid":"PMC13013537","openalex_id":"https://openalex.org/W7134902422","authors":[],"funders":[],"total_grants":0,"fwci":14.7643,"citation_percentile":0.98771997,"influential_citations":0,"citation_trend":[{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1698015/pdf","host_type":"journal"},{"url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1698015/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fcell.2026.1698015/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fcell.2026.1698015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41890909","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13013537/","host_type":"repository"},{"url":"https://doaj.org/article/4912efd3e85d43068e3c988184038ad1","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13013537/pdf/fcell-14-1698015.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC13013537","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC13013537?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Genetic Syndromes and Imprinting","Epigenetics and DNA Methylation","RNA modifications and cancer"],"mesh_terms":[],"keywords":["Imprinting (psychology)","Genomic imprinting","MEG3","DNA methylation","Angiogenesis","Organogenesis","Carcinogenesis","Locus (genetics)","Embryonic stem cell","Embryonic development","Noncoding RNA","Epigenetic regulation","Cancer Epigenetics","Loss Of Imprinting (Loi)","H19/Igf2 Locus"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T00:51:45.460603Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}