{"doi":"10.3389/fcell.2025.1714104","title":"Editorial: Targeting pulmonary endothelium in acute lung injury and acute respiratory distress syndrome","abstract":"Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain major causes of mortality in critical care, despite advances in mechanical ventilation and supportive care (1,2). The pulmonary endothelium, a thin, semipermeable barrier lining the pulmonary vasculature, plays a central role in the pathogenesis of ALI/ARDS. Endothelial dysfunction drives vascular leak, inflammation, and coagulation abnormalities-hallmark features of ALI/ARDS that culminate in alveolar edema and hypoxemia (3,4). This Research Topic, \"Targeting Pulmonary Endothelium in Acute Lung Injury and Acute Respiratory Distress Syndrome,\" brings together 13 articles that dissect the molecular mechanisms of endothelial injury, identify novel biomarkers, and explore endothelial-targeted therapeutic strategies, addressing critical gaps in our understanding of these devastating conditions.","journal":"Frontiers in Cell and Developmental Biology","year":2025,"id":577191,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":15693,"name":"You Shang","orcid":"0000-0003-4097-6131","position":1,"is_corresponding":false},{"id":1027786,"name":"Guochang Hu","orcid":"0000-0002-7054-7867","position":2,"is_corresponding":false},{"id":1486381,"name":"Lulong Bo","orcid":"0000-0001-6787-1837","position":0,"is_corresponding":true}],"reference_count":6,"raw_metadata":null,"created_at":"2026-07-19T02:58:04.622308Z","pmid":"41133218","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}