{"doi":"10.3389/fcell.2024.1471251","title":"Editorial: Glycocalyx in physiology and vascular related diseases–volume II","abstract":"The glycocalyx, a complex mesh of glycoproteins and polysaccharides enveloping the surface of various cells, has emerged as a pivotal element in both health and disease. This ubiquitous structure is not merely a passive barrier but a dynamic participant in numerous physiological processes and a critical mediator in pathological states. Insights gleaned from recent studies underscore the potential of the glycocalyx as a therapeutic target, promising new avenues for treating a spectrum of vascular-related diseases.In this collection, the glycocalyx is investigated in various contexts, including atherosclerosis, bladder cancer, inflammation, hypertension, sepsis, and trauma. It highlights the importance of understanding the mechanisms by which the structure and composition of the glycocalyx are modified, particularly in response to pathological changes. In the realm of oncology, Torai Enomoto et al. focus on the glycocalyx's role in bladder cancer. They utilize imaging techniques to visualize the aberrant glycocalyx in cancers, particularly invasive urothelial carcinomas. The distinctive staining of Vicia villosa lectin (VVL) in these carcinomas suggests its potential as a marker for cancer invasiveness. These findings underscore the glycocalyx's involvement in cancer progression and highlight VVL as a promising target for future drug development strategies. The endothelial glycocalyx is a multifaceted structure that acts as a dynamic regulator in various physiological and pathological processes. From regulating blood flow and endothelial functionality to influencing atherosclerosis and cancer progression and to managing inflammation, the glycocalyx is integral to maintaining vascular health. Understanding its complex interactions and responses opens new therapeutic avenues for treating a wide range of diseases. As research progresses, targeting critical glycocalyx components, such as glycosaminoglycans and proteoglycans, could revolutionize medical treatments, providing more effective and personalized healthcare solutions.","journal":"Frontiers in Cell and Developmental Biology","year":2024,"id":488816,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":309328,"name":"Bingmei M. Fu","orcid":"0000-0001-9343-5895","position":1,"is_corresponding":false},{"id":479576,"name":"Ye Zeng","orcid":"0000-0001-5440-6194","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:08:19.655720Z","pmid":"39175873","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}