{"doi":"10.3389/fcell.2022.982199","title":"Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models","abstract":"There is an unmet need for novel and efficacious therapeutics for regenerating injured articular cartilage in progressive osteoarthritis (OA) and/or trauma. Mesenchymal stem cells (MSCs) are particularly promising for their chondrogenic differentiation, local healing environment modulation, and tissue- and organism-specific activity; however, despite early in vivo success, MSCs require further investigation in highly-translatable models prior to disseminated clinical usage. Large animal models, such as canine, porcine, ruminant, and equine models, are particularly valuable for studying allogenic and xenogenic human MSCs in a human-like osteochondral microenvironment, and thus play a critical role in identifying promising approaches for subsequent clinical investigation. In this mini-review, we focus on [1] considerations for MSC-harnessing studies in each large animal model, [2] source tissues and organisms of MSCs for large animal studies, and [3] tissue engineering strategies for optimizing MSC-based cartilage regeneration in large animal models, with a focus on research published within the last 5 years. We also highlight the dearth of standard assessments and protocols regarding several crucial aspects of MSC-harnessing cartilage regeneration in large animal models, and call for further research to maximize the translatability of future MSC findings.","journal":"Frontiers in Cell and Developmental Biology","year":2022,"id":243857,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":589252,"name":"Pin Ha","orcid":"0000-0002-8934-0874","position":1,"is_corresponding":false},{"id":647021,"name":"Crystal Xiao","orcid":null,"position":2,"is_corresponding":false},{"id":876946,"name":"Sang Yub Kim","orcid":null,"position":3,"is_corresponding":false},{"id":876406,"name":"Andrew R. Jensen","orcid":"0000-0002-1807-920X","position":4,"is_corresponding":false},{"id":370868,"name":"Jeremiah T. Easley","orcid":"0000-0002-7294-6407","position":5,"is_corresponding":false},{"id":876407,"name":"Qingqiang Yao","orcid":"0000-0002-5037-5412","position":6,"is_corresponding":false},{"id":589254,"name":"Xinli Zhang","orcid":"0000-0002-9458-3985","position":7,"is_corresponding":false},{"id":876945,"name":"Timothy P. Liu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T00:23:20.901576Z","pmid":"36147737","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}