{"doi":"10.3389/fcell.2022.1026326","title":"Editorial: Mechanistic studies of genome integrity, environmental health, and cancer etiology","abstract":"Genomic DNA in all cell types is exposed to insults from endogenous sources, such as oxidative stress, as well as exogenous sources, including environmental genotoxins and anti-cancer therapeutics. Deficiencies in genome integrity maintenance pathways have been implicated in the etiology of cancer and other disease states. To mitigate the debilitating genomic lesions, cells have evolved many different pathways to sense, repair, and signal in response to such challenges. Research studies focused on understanding genome integrity mechanisms have utilized a variety of model organisms and cuttingedge technologies at the molecular, cellular, organismal, and ecological levels. Mechanistic studies that help define the process of genome integrity maintenance, the impact of such mechanisms on environmental health, and their role in cancer etiology are highly significant and have led to new ways of diagnosing and treating cancers and other human diseases. Because of the many advances in this area of research over the past few years, this Research Topic intends to provide the latest insights on the field of genome integrity and to discuss the trends of current and future studies aimed at improving our understanding of disease pathogenesis and treatment. Here, we provide an editorial to summarize these seven research articles and two review articles.","journal":"Frontiers in Cell and Developmental Biology","year":2022,"id":311674,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336357,"name":"Jianjun Zhao","orcid":"0000-0003-3008-3655","position":1,"is_corresponding":false},{"id":390936,"name":"Michael G. Kemp","orcid":"0000-0001-8203-0745","position":2,"is_corresponding":false},{"id":285722,"name":"Robert W. Sobol","orcid":"0000-0001-7385-3563","position":3,"is_corresponding":false},{"id":336353,"name":"Shan Yan","orcid":"0000-0001-8106-6295","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T00:33:32.327694Z","pmid":"36247007","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}