{"doi":"10.3389/fcell.2021.834280","title":"Editorial: Glycocalyx in Physiology and Vascular Related Diseases","abstract":"Glycocalyx (GCX) covers the surface of every mammalian cell. It is closely associated with various physiological and pathophysiological events, including cytoskeleton remodeling, vascular leakage, angiogenesis, and tumor growth and metastasis. Components of GCX are promising biomarkers for many vascular-related diseases, such as sepsis, shock, coronary artery disease, COVID-19, hypertension, diabetes, ischemia-reperfusion injury, and pre-eclampsia. They are also the critical elements involved in the cell-cell and cell-external environment crosstalk in these diseases. The structure of GCX can be modified by bioactive serum constituents, drugs, mechanical forces, and other factors. As an essential signaling mediator, GCX governs the transduction of the extracellular signals into cellular responses. GCX mediated signaling is involved in the cell proliferation, apoptosis, migration, adhesion, autophagy, oxidative stress, angiogenesis, and metastasis.","journal":"Frontiers in Cell and Developmental Biology","year":2022,"id":299750,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":309328,"name":"Bingmei M. Fu","orcid":"0000-0001-9343-5895","position":1,"is_corresponding":false},{"id":479576,"name":"Ye Zeng","orcid":"0000-0001-5440-6194","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:31:49.412501Z","pmid":"35059404","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}