{"doi":"10.3389/fcell.2021.807345","title":"Arginylation Regulates G-protein Signaling in the Retina","abstract":"Arginylation is a post-translational modification mediated by the arginyltransferase (Ate1). We recently showed that conditional deletion of Ate1 in the nervous system leads to increased light-evoked response sensitivities of ON-bipolar cells in the retina, indicating that arginylation regulates the G-protein signaling complexes of those neurons and/or photoreceptors. However, none of the key players in the signaling pathway were previously shown to be arginylated. Here we show that G α t1, G β 1, RGS6, and RGS7 are arginylated in the retina and RGS6 and RGS7 protein levels are elevated in Ate1 knockout, suggesting that arginylation plays a direct role in regulating their protein level and the G-protein-mediated responses in the retina.","journal":"Frontiers in Cell and Developmental Biology","year":2022,"id":290779,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9467,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":74955,"name":"Junling Wang","orcid":"0000-0002-5839-4685","position":1,"is_corresponding":false},{"id":661500,"name":"Pavan Vedula","orcid":"0000-0002-9914-0008","position":2,"is_corresponding":false},{"id":258003,"name":"Hsin‐Yao Tang","orcid":"0000-0003-1838-018X","position":3,"is_corresponding":false},{"id":74961,"name":"Anna Kashina","orcid":"0000-0002-0243-6866","position":4,"is_corresponding":false},{"id":488622,"name":"Dawei Dong","orcid":"0000-0002-0112-6233","position":5,"is_corresponding":false},{"id":737759,"name":"Marie E. Fina","orcid":null,"position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T00:30:30.639224Z","pmid":"35127722","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}