{"doi":"10.3389/fcell.2021.690373","title":"Oleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction","abstract":"Reproduction comes at a cost, including accelerated death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed in low-reproduction conditions. To understand how increased reproduction affects lifespan and fat metabolism, we examined mated worms; we find that a Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation of oleic acid (OA), the immediate downstream product of FAT-7 activity, restores fat storage and completely rescues mating-induced death, while other fatty acids cannot. OA-mediated lifespan restoration is also observed in C. elegans mutants suffering increased death from short-term mating, and in mated C. remanei females, indicating a conserved role of oleic acid in post-mating lifespan regulation. Our results suggest that increased reproduction can be uncoupled from the costs of reproduction from somatic longevity regulation if provided with the limiting lipid, oleic acid.","journal":"Frontiers in Cell and Developmental Biology","year":2021,"id":186504,"datarank":0.7409857037756324,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.277329335771885,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.277329335771885,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":18,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9588,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":567352,"name":"Cheng Shi","orcid":"0000-0003-0365-8273","position":1,"is_corresponding":false},{"id":744650,"name":"Jasmine M. Ashraf","orcid":"0000-0003-0127-9835","position":2,"is_corresponding":false},{"id":256012,"name":"Salman Sohrabi","orcid":"0000-0002-1631-7788","position":3,"is_corresponding":false},{"id":256015,"name":"Coleen T. Murphy","orcid":"0000-0002-8257-984X","position":4,"is_corresponding":false},{"id":744649,"name":"Leo Sungwong Choi","orcid":"0000-0001-8850-0832","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:48:46.850806Z","pmid":"34179018","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}