{"doi":"10.3389/fbiom.2023.1279367","title":"In vivo validation of a mechanically adaptive microfluidic intracortical device as a platform for sustained local drug delivery","abstract":"Introduction: Intracortical microelectrodes (IME) are vital to properly functioning brain-computer interfacing (BCI). However, the recording electrodes have shown a steady decline in performance after implantation, mainly due to chronic inflammation. Compliant materials have been explored to decrease differential strain resulting in lower neural inflammation. We have previously developed a fabrication method for creating mechanically adaptive microfluidic probes made of a cellulose nanocrystal (CNC) polymer nanocomposite material that can become compliant after implantation. Here, we hypothesized that our device, would have a similar tissue response to the industry standard, allowing drug delivery therapeutics to improve neural inflammation in the future. Methods: RNA expression analysis was performed to determine the extent of neural inflammation and oxidative stress in response to the device compared to controls and to naïve shame tissue. Results: Results presented for both four- and eight-weeks post-implantations suggest that our device offers a promising platform technology that can be used to deliver therapeutic strategies to improve IME performance.","journal":"Frontiers in Biomaterials Science","year":2023,"id":353140,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9519,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":813328,"name":"Lindsey N. Druschel","orcid":"0000-0001-9457-1944","position":1,"is_corresponding":false},{"id":814982,"name":"Natalie N. Mueller","orcid":"0000-0003-0336-3686","position":2,"is_corresponding":false},{"id":1099362,"name":"Danielle L. Sarno","orcid":"0000-0003-4782-0287","position":3,"is_corresponding":false},{"id":1099363,"name":"Kaela Gisser","orcid":"0009-0004-2223-1157","position":4,"is_corresponding":false},{"id":814985,"name":"Allison Hess‐Dunning","orcid":"0000-0003-4060-1145","position":5,"is_corresponding":false},{"id":406153,"name":"Jeffrey R. Capadona","orcid":"0000-0001-8030-6947","position":6,"is_corresponding":false},{"id":406150,"name":"Youjoung Kim","orcid":"0000-0002-1373-0913","position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-19T01:12:58.542950Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}