{"doi":"10.3389/fbioe.2022.1032571","title":"Hydrogen sulfide activatable metal-organic frameworks for Fluorescence Imaging-Guided Photodynamic Therapy of colorectal cancer","abstract":"Photodynamic therapy (PDT) is a promising alternative and palliative therapeutic strategy for colorectal cancer (CRC). A novel photosensitizer with higher selectivity for CRC and fewer side effects is vital for clinical application. Given that the overexpression of hydrogen sulfide (H 2 S) in CRC, it is expected to provide a selective stimulus for activatable photosensitizers that in respond to the specific microenvironment. Herein, we report a novel development of metal-organic frameworks (MOFs) composed of meso-Tetra (4-carboxyphenyl) porphine (TCPP) and ferric ion (Fe 3+ ) through a facile one-pot process. Experiments both in vitro and in vivo reveal that the MOF is capable of depredating in response to the high content of H 2 S in tumor microenvironment of CRC. Accompanying with the degradation and release of TCPP, the fluorescence and photosensitivity effect is switched from “off” to “on”, enabling the MOF to serve as a H 2 S activatable nano-photosensitizer for real-time fluorescence imaging-guided and targeted PDT of CRC.","journal":"Frontiers in Bioengineering and Biotechnology","year":2022,"id":245621,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":881365,"name":"Mao Huang","orcid":null,"position":1,"is_corresponding":false},{"id":880727,"name":"Zixuan Wei","orcid":"0000-0002-8854-279X","position":2,"is_corresponding":false},{"id":880728,"name":"Jiawen He","orcid":"0009-0007-7754-825X","position":3,"is_corresponding":false},{"id":881366,"name":"Yunong Ma","orcid":null,"position":4,"is_corresponding":false},{"id":880729,"name":"Cuixia Lu","orcid":"0000-0002-6074-885X","position":5,"is_corresponding":false},{"id":344698,"name":"Albert J. Jin","orcid":"0000-0003-3826-1081","position":6,"is_corresponding":false},{"id":880730,"name":"Zhixiong Wang","orcid":"0000-0003-0879-5728","position":7,"is_corresponding":false},{"id":880731,"name":"Liewei Wen","orcid":"0000-0002-4657-6457","position":8,"is_corresponding":false},{"id":880726,"name":"Honghui Li","orcid":"0000-0002-6831-1919","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T00:23:39.284121Z","pmid":"36277384","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}