{"doi":"10.3389/fbioe.2020.00315","title":"Development of Multifunctional Biopolymeric Auto-Fluorescent Micro- and Nanogels as a Platform for Biomedical Applications","abstract":"The emerging field of theranostics for advanced healthcare has raised the demand for effective and safe delivery systems consisting of therapeutics and diagnostics agents in a single monarchy. This requires the development of multi-functional bio-polymeric systems for efficient image-guided therapeutics. This study reports the development of size-controlled (micro-to-nano) auto-fluorescent biopolymeric hydrogel particles of chitosan and hydroxyethyl cellulose (HEC) synthesized using water-in-oil emulsion polymerization technique. Sustainable resource linseed oil-based polyol is introduced as an element of hydrophobicity with an aim to facilitate their ability to traverse the blood-brain barrier (BBB). These linseed oil-based polyol nanogels are demonstrated to have salient features such as biocompatibility, stability, high cellular uptake by a variety of host cells, and ability to transmigrate across an in vitro BBB model. Interestingly, these unique nanogel particles exhibited auto-fluorescence at a wide range of wavelengths 450 - 780 nm on excitation at 405 nm whereas excitation at 710 nm gives emission at 810 nm. In conclusion, this study proposes the developed bio-polymeric fluorescent micro- and nano- gels as a potential theranostic tool for central nervous system (CNS) drug delivery and image-guided therapy.","journal":"Frontiers in Bioengineering and Biotechnology","year":2020,"id":94190,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9491,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":469576,"name":"Venkata Atluri","orcid":"0000-0002-8070-6745","position":1,"is_corresponding":false},{"id":288696,"name":"Andrea Raymond","orcid":"0000-0003-4249-2296","position":2,"is_corresponding":false},{"id":469577,"name":"Ajeet Kaushik","orcid":"0000-0003-4206-1541","position":3,"is_corresponding":false},{"id":470574,"name":"Tiyash Parira","orcid":null,"position":4,"is_corresponding":false},{"id":470575,"name":"Zaohua Huang","orcid":null,"position":5,"is_corresponding":false},{"id":469578,"name":"Andriy Durygin","orcid":"0000-0003-3837-7949","position":6,"is_corresponding":false},{"id":295750,"name":"Asahi Tomitaka","orcid":"0000-0002-1234-6047","position":7,"is_corresponding":false},{"id":470576,"name":"Roozbeh Nikkhah-Moshaie","orcid":null,"position":8,"is_corresponding":false},{"id":469579,"name":"Atul Vashist","orcid":"0000-0002-2843-1166","position":9,"is_corresponding":false},{"id":470577,"name":"Marisela Agudelo","orcid":null,"position":10,"is_corresponding":false},{"id":275204,"name":"Hitendra S. Chand","orcid":"0000-0002-0574-9307","position":11,"is_corresponding":false},{"id":470578,"name":"Ilyas Saytashev","orcid":null,"position":12,"is_corresponding":false},{"id":364230,"name":"Jessica C. Ramella‐Roman","orcid":"0000-0002-5710-6004","position":13,"is_corresponding":false},{"id":254216,"name":"Madhavan Nair","orcid":"0009-0009-9110-5337","position":14,"is_corresponding":false},{"id":469575,"name":"Arti Vashist","orcid":"0000-0002-7519-1863","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T22:32:04.778261Z","pmid":"32426338","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}