{"doi":"10.3389/adar.2024.13706","title":"Editorial: 8th biennial international drug and alcohol research society conference 2022","abstract":"priorities, there is need for new research strategies and targets for treating SUDs, as currently available therapies help few that could benefit (2). To address unmet needs in SUD treatment new frontiers in AI beyond CHATGPT with large quantitative AI, and combination with advance sensing may be useful to make new drugs for treating SUDs.This special issue was put together to highlight the research advances and contributions made by some attendees of the 2022, 8 th biennial International Drug and Alcohol Research Society (IDARS) Conference in Nice France. The goal of this special issue was to capture and present research data, reviews and discuss the state of knowledge and future of drug and alcohol addiction that continues to be a global problem. Two research articles provided preclinical data using in-vivo and in-vitro techniques to evaluate the effects of alcohol, and four comprehensive review articles covering diverse molecular, gut microbiome, neuroimmune effects of drugs and alcohol. 2+ -and voltage-gated K + channels of big conductance", investigated the effects of alcohol and pregnenolone (PREG) interaction on cerebral arteries in male and female C57BL/6J mice, to address the consequences in people who may be taking pregnenolone supplements while binge drinking. The study showed that PREG at low concentrations synergized with alcohol in middle cerebral artery (MCA) constriction. Yet this synergism was lost as both PREG and alcohol were probed at higher doses. Other in-vitro electrophysiological data acquisition, and measurements of cerebral artery diameter provided evidence that PREG and alcohol converge on a common pathway to evoke cerebral artery constriction. Furthermore Ca 2+ and voltage-gated K + large conductance channels (BK channel) inhibition by PREG and alcohol involves disruption of allosteric coupling to Ca 2+ -driven gating.As PREG regulates several physiological processes, the study highlights that a combination of PREG and alcohol may affect brain artery function. Of note is that AUDs is occurring in population aged 65 and older, that may be at risk for cerebrovascular ischemic conditions.","journal":"Advances in Drug and Alcohol Research","year":2025,"id":562076,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":414617,"name":"Emmanuel S. Onaivi","orcid":"0000-0002-7561-8927","position":0,"is_corresponding":true}],"reference_count":2,"raw_metadata":null,"created_at":"2026-07-19T02:56:01.883848Z","pmid":"40027880","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}