{"doi":"10.3388/jspaci.5.97","title":"THE COMBINED EFFECTS OF INHALED DISODIUM CROMOGLYCATE WITH β-STIMULANT ON HYPEROSMOLAR INDUCED BROCHOSPASM","abstract":null,"journal":"Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology","year":1991,"id":685742,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1791586,"name":"Sankei Nishima","orcid":null,"position":1,"is_corresponding":false},{"id":1791585,"name":"Sohei Kano","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"THE COMBINED EFFECTS OF INHALED DISODIUM CROMOGLYCATE WITH β-STIMULANT ON HYPEROSMOLAR INDUCED BROCHOSPASM","abstract":"To investigate the combined effects of inhaled DSCG with β-stimulant for the prevention of bronchospasm induced by hyperosmolar challenges, 10 asthmatic children had eight hyperosmolar challenge tests in a randomised order. 3 tests were performed at 15min after the inhalation of either saline (control: C), DSCG (D), or salbutamol (S). 5 tests were performed at 180min after the inhalation of either C, D, S, salbutamol followed by DSCG (S→D) or DSCG mixed with salbutamol (S+D). Although FEV1.0 significantly increased untill 180min after inhalation in groups of S, S→D and S+D, there were no significant differences between each group. No synergetic effect occurred in the bronchodilating response to the inhalation of DSCG with salbutamol. In both the D and S groups, the dose of hypersaline provoking the 20% decrement in FEV1.0 (PD20) increased at 15min after inhalation. This protective effect of inhaled DSCG almost disappeared at 180min. PD20 in both the S→D and S+D groups significantly increased as compared to the S group at 180min after inhalation (p<0.05). There were, however, no significant differences in PD20 between the S→D and S+D groups. To evaluate further whether PD20 was influenced by doses of inhaled DSCG, PD20 was measured at 180min after the inhalation of 10mg/ml or 20mg/ml of DSCG. PD20 did not significantly increase in 20mg/ml of DSCG.This suggests that the combination of inhaled DSCG with salbutamol may produce a synergetic protective effect against the hyperosmolar challenge test.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W2330697336","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.18217367,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jspaci1987/5/2/5_2_97/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jspaci1987/5/2/5_2_97/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.3388/jspaci.5.97","host_type":"journal"}],"fields_of_study":["Asthma and respiratory diseases","Respiratory and Cough-Related Research","Inhalation and Respiratory Drug Delivery"],"mesh_terms":[],"keywords":["Salbutamol","Inhalation","Stimulant","Medicine","Asthma","Anesthesia","Bronchospasm","Bronchodilation","Saline","Pharmacology","Bronchodilator","Internal medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T17:30:40.686180Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}