{"doi":"10.33612/diss.214061634","title":"CINflammatory: the multi-layered relationship between chromosomal instability and inflammation","abstract":null,"journal":null,"year":null,"id":617695,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1014659,"name":"Christy Hong","orcid":"0000-0002-7360-5823","position":1,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CINflammatory: the multi-layered relationship between chromosomal instability and inflammation","abstract":"Chromosomal instability (CIN) is characterized by continuous errors in chromosome segregation during mitosis and is observed frequently in cancer. The process of CIN most of the time leads to structural and numerical chromosome abnormalities, a state known as aneuploidy. It is important to note that aneuploidy can exist without CIN, for example in the case of Down syndrome where amplification of chromosome 21 exists in an otherwise stable karyotype. Generally, chromosomal instability and aneuploidy are accompanied by detrimental effects on cells. In the majority of normal cells, CIN and aneuploidy have been found to decrease proliferation rates and aneuploidies during embryogenesis are mostly lethal. Yet, 70-90% of cancers are aneuploid and chromosomal instability is a known major driver of tumor evolution, found in most of the advanced cancer. By promoting tumor evolution, CIN has been shown to promote drug resistance, immune evasion, and metastasis. The paradoxical nature of chromosomal instability and aneuploidy can be better comprehended by a thorough dissection of the context they exist in. This is especially relevant when studying CIN and aneuploidy in tumor settings. In a tumor, CIN/aneuploid cancer cells are exposed to a plethora of other microenvironment components, such as immune cells and stromal cells. Understanding the interplay between CIN/aneuploid cancer cells and their surrounding microenvironment and dissecting the pathways that are engaged would aid us to decipher the role CIN/aneuploidy plays, and whether it is beneficial or detrimental.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19910364","pmcid":null,"openalex_id":"https://openalex.org/W4225138712","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://pure.rug.nl/ws/files/214061636/Title_and_contents.pdf","host_type":""},{"url":"https://pure.rug.nl/ws/files/214061636/Title_and_contents.pdf","host_type":""},{"url":"https://doi.org/10.33612/diss.214061634","host_type":""},{"url":"https://research.rug.nl/en/publications/4329abfa-beaf-4e41-830f-cfd9c5b20b15","host_type":"repository"}],"fields_of_study":["Phagocytosis and Immune Regulation","Microtubule and mitosis dynamics","Caveolin-1 and cellular processes"],"mesh_terms":[],"keywords":["Aneuploidy","Chromosome instability","Biology","Context (archaeology)","Cancer","Genome instability","Cancer research","Cancer cell","Chromosome","Metastasis","Genetics","Gene","DNA damage","DNA"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:24:07.951113Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}