{"doi":"10.33549/physiolres.934734","title":"Age-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria","abstract":"<jats:p>Mitochondria play an important role in the cell aging process.\nChanges in calcium homeostasis and/or increased reactive\noxygen species (ROS) production lead to the opening of\nmitochondrial permeability transition pore (MPTP), depolarization\nof the inner mitochondrial membrane, and decrease of ATP\nproduction. Our work aimed to monitor age-related changes in\nthe Ca2+ ion effect on MPTP and the ability of isolated rat liver\nmitochondria to accumulate calcium. The mitochondrial calcium\nretention capacity (CRC) was found to be significantly affected by\nthe age of rats. Measurement of CRC values of the rat liver\nmitochondria showed two periods when 3 to 17-week old rats\nwere tested. 3-week and 17-week old rats showed lower CRC\nvalues than 7-week old animals. Similar changes were observed\nwhile testing calcium-induced swelling of rat liver mitochondria.\nThese findings indicate that the mitochondrial energy production\nsystem is more resistant to calcium-induced MPTP opening\naccompanied by the damaging effect of ROS in adult rats than in\nyoung and aged animals.</jats:p>","journal":"Physiological Research","year":2021,"id":675938,"datarank":0.30983214193673675,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.017945619578439733,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.017945619578439733,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":4,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1766141,"name":"Z Drahota","orcid":null,"position":1,"is_corresponding":false},{"id":1766142,"name":"O Kučera","orcid":null,"position":2,"is_corresponding":false},{"id":1766143,"name":"Z Červinková","orcid":null,"position":3,"is_corresponding":false},{"id":1766140,"name":"R Endlicher","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Age-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria","abstract":"<jats:p>Mitochondria play an important role in the cell aging process.\nChanges in calcium homeostasis and/or increased reactive\noxygen species (ROS) production lead to the opening of\nmitochondrial permeability transition pore (MPTP), depolarization\nof the inner mitochondrial membrane, and decrease of ATP\nproduction. Our work aimed to monitor age-related changes in\nthe Ca2+ ion effect on MPTP and the ability of isolated rat liver\nmitochondria to accumulate calcium. The mitochondrial calcium\nretention capacity (CRC) was found to be significantly affected by\nthe age of rats. Measurement of CRC values of the rat liver\nmitochondria showed two periods when 3 to 17-week old rats\nwere tested. 3-week and 17-week old rats showed lower CRC\nvalues than 7-week old animals. Similar changes were observed\nwhile testing calcium-induced swelling of rat liver mitochondria.\nThese findings indicate that the mitochondrial energy production\nsystem is more resistant to calcium-induced MPTP opening\naccompanied by the damaging effect of ROS in adult rats than in\nyoung and aged animals.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34717067","pmcid":"PMC8815472","openalex_id":"https://openalex.org/W4225596112","authors":[],"funders":[],"total_grants":0,"fwci":0.2223,"citation_percentile":0.50315406,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.33549/physiolres.934734","host_type":"journal"},{"url":"https://doi.org/10.33549/physiolres.934734","host_type":"publisher"}],"fields_of_study":["Mitochondrial Function and Pathology","Metabolism and Genetic Disorders","Adipose Tissue and Metabolism"],"mesh_terms":["Mitochondria, Liver","Animals","Rats","Rats, Wistar","Aging","Male","Mitochondrial Permeability Transition Pore"],"keywords":["Mitochondrial permeability transition pore","Mitochondrion","MPTP","Calcium","Membrane potential","Chemistry","Reactive oxygen species","Endocrinology","Inner mitochondrial membrane","Internal medicine","Depolarization","Permeability (electromagnetism)","Calcium metabolism","Membrane permeability","Homeostasis","Cell biology","Biology","Biochemistry","Programmed cell death","Membrane","Apoptosis","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:53:57.818322Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}