{"doi":"10.3350/cmh.2024.0835","title":"Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000–2021","abstract":"BACKGROUND/AIMS: Alcohol represents a leading burden of disease worldwide, including alcohol use disorder (AUD) and alcohol-related liver disease (ALD). We aim to assess the global burden of AUD, ALD, and alcohol-attributable primary liver cancer between 2000-2021. METHODS: We registered the global and regional trends of AUD, ALD, and alcohol-related liver cancer using data from the Global Burden of Disease 2021 Study, the largest and most up-to-date global epidemiology database. We estimated the annual percent change (APC) and its 95% confidence interval (CI) to assess changes in age-standardized rates over time. RESULTS: In 2021, there were 111.12 million cases of AUD, 3.02 million cases of ALD, and 132,030 cases of alcohol-attributable primary liver cancer. Between 2000 and 2021, there was a 14.66% increase in AUD, a 38.68% increase in ALD, and a 94.12% increase in alcohol-attributable primary liver cancer prevalence. While the age-standardized prevalence rate for liver cancer from alcohol increased (APC 0.59%; 95% confidence interval [CI] 0.52 to 0.67%) over these years, it decreased for ALD (APC -0.71%; 95% CI -0.75 to -0.67%) and AUD (APC -0.90%; 95% CI -0.94 to -0.86%). There was significant variation by region, socioeconomic development level, and sex. During the last years (2019-2021), the prevalence, incidence, and death of ALD increased to a greater extent in females. CONCLUSION: Given the high burden of AUD, ALD, and alcohol-attributable primary liver cancer, urgent measures are needed to prevent them at both global and national levels.","journal":"Clinical and Molecular Hepatology","year":2025,"id":508939,"datarank":0.8721105257209059,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.255479446094909,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.255479446094909,"corpus_percentile":76.91653129109615,"corpus_rank":2985,"citation_count":60,"citer_count":43,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7446,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":480718,"name":"Luis Antonio Díaz","orcid":"0000-0002-8540-4930","position":1,"is_corresponding":false},{"id":1230437,"name":"Kanokphong Suparan","orcid":"0000-0002-6853-7387","position":2,"is_corresponding":false},{"id":1362597,"name":"Primrose Tothanarungroj","orcid":null,"position":3,"is_corresponding":false},{"id":1362598,"name":"Supapitch Sirimangklanurak","orcid":null,"position":4,"is_corresponding":false},{"id":1361432,"name":"Thanida Auttapracha","orcid":"0000-0001-7726-5814","position":5,"is_corresponding":false},{"id":425733,"name":"Hanna Blaney","orcid":"0000-0003-4919-9519","position":6,"is_corresponding":false},{"id":1230901,"name":"Banthoon Sukphutanan","orcid":null,"position":7,"is_corresponding":false},{"id":1362599,"name":"Yanfang Pang","orcid":null,"position":8,"is_corresponding":false},{"id":1362600,"name":"Siwanart Kongarin","orcid":null,"position":9,"is_corresponding":false},{"id":628736,"name":"Francisco Idalsoaga","orcid":"0000-0001-5607-0698","position":10,"is_corresponding":false},{"id":480720,"name":"Eduardo Fuentes–López","orcid":"0000-0002-0141-0226","position":11,"is_corresponding":false},{"id":239673,"name":"Lorenzo Leggio","orcid":"0000-0001-7284-8754","position":12,"is_corresponding":false},{"id":291021,"name":"Mazen Noureddin","orcid":"0000-0003-2127-2040","position":13,"is_corresponding":false},{"id":1361433,"name":"Trenton M. 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