{"doi":"10.3346/jkms.2022.37.e29","title":"Clinical Effect of Hepatitis B Virus on COVID-19 Infected Patients: A Nationwide Population-Based Study Using the Health Insurance Review & Assessment Service Database","abstract":null,"journal":"Journal of Korean Medical Science","year":2022,"id":654708,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":157641,"name":"Young Kul Jung","orcid":"0000-0002-6566-1382","position":1,"is_corresponding":false},{"id":1421418,"name":"Hyung Joon Yim","orcid":"0000-0002-6036-2754","position":2,"is_corresponding":false},{"id":1708752,"name":"Gi Hyeon Seo","orcid":"0000-0001-7414-0258","position":3,"is_corresponding":false},{"id":1708751,"name":"Jung Wan Choe","orcid":"0000-0003-0634-5141","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical Effect of Hepatitis B Virus on COVID-19 Infected Patients: A Nationwide Population-Based Study Using the Health Insurance Review & Assessment Service Database","abstract":"BACKGROUND: Several studies have recently suggested that liver disease and cirrhosis were risk factors for poor outcomes in patients with coronavirus disease 2019 (COVID-19) infections. However, no large data study has reported the clinical course of COVID-19 patients with chronic hepatitis B virus (HBV) infections. This study investigated whether HBV infection had negative impacts on the clinical outcomes of COVID-19 patients. METHODS: We performed a nationwide population-based cohort study with 19,160 COVID-19-infected patients in 2020 from the Korean Health Insurance Review and Assessment database. The clinical outcomes of COVID-19 patients with chronic HBV infections were assessed and compared to those of non-HBV-infected patients. RESULTS: Of the 19,160 patients diagnosed with COVID-19, 675 (3.5%) patients had chronic HBV infections. The HBV-infected patients were older and had more commodities than the non-HBV infected COVID-19 patients. During the observation period, COVID-19-related mortality was seen in 1,524 (8.2%) of the non-HBV-infected 18,485 patients, whereas 91 (13.5%) in HBV-infected 675 patients died of COVID-19 infection. Compared to patients without HBV infections, a higher proportion of patients with chronic HBV infections required intensive care unit (ICU) admission and had organ failures. However, odds ratios for mortality, ICU admission, and organ failure were comparable between the two groups after adjusting for age, sex, and comorbid diseases including liver cirrhosis and hepatocellular carcinoma. CONCLUSION: COVID-19-infected patients with HBV infections showed worse clinical courses than non-HBV-infected COVID-19 patients. However, after adjustment, chronic HBV infection itself does not seem to affect the clinical outcomes in COVID-19 patients.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35075828","pmcid":"PMC8787805","openalex_id":"https://openalex.org/W4205436962","authors":[],"funders":[],"total_grants":0,"fwci":4.1569,"citation_percentile":0.94861901,"influential_citations":0,"citation_trend":[{"year":2022,"count":5},{"year":2023,"count":11},{"year":2024,"count":8},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.3346/jkms.2022.37.e29","host_type":"journal"},{"url":"https://doi.org/10.3346/jkms.2022.37.e29","host_type":"GOLD"},{"url":"https://doi.org/10.3346/jkms.2022.37.e29","host_type":"publisher"},{"url":"https://jkms.org/pdf/10.3346/jkms.2022.37.e29","host_type":"publisher"},{"url":"https://jkms.org/DOIx.php?id=10.3346/jkms.2022.37.e29","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35075828","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8787805","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8787805","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8787805?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Hepatitis B Virus Studies","COVID-19 Clinical Research Studies","Hepatitis C virus research","Medicine","Antiviral Agents","COVID-19","Cell Line, Tumor","Comorbidity","Female","Hepatitis B virus","Hepatitis B, Chronic","Humans","Kaplan-Meier Estimate","Length of Stay","Male","Middle Aged","Organ Dysfunction Scores","SARS-CoV-2","Treatment Outcome"],"mesh_terms":["COVID-19","SARS-CoV-2","Antiviral Agents","Female","Hepatitis B virus","Humans","Length of Stay","Male","Middle Aged","Comorbidity","Treatment Outcome","Hepatitis B, Chronic","Cell Line, Tumor","Kaplan-Meier Estimate","Organ Dysfunction Scores"],"keywords":["Medicine","Coronavirus disease 2019 (COVID-19)","Hepatitis a virus","Population","Health insurance","Virology","Hepatitis B virus","Health services","Virus","Health care","Internal medicine","Environmental health","Risk factor","Antiviral","Coronavirus","chronic hepatitis B","Covid-19","Sars-cov-2","Coronavirus Disease 2019"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T07:57:29.702866Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}