{"doi":"10.3345/kjp.2016.59.11.s57","title":"Targeted busulfan and fludarabine-based conditioning for bone marrow transplantation in chronic granulomatous disease","abstract":null,"journal":"Korean Journal of Pediatrics","year":2016,"id":617329,"datarank":0.3615345923117834,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.12011890544666837,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.12011890544666837,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":649228,"name":"Hyoung Jin Kang","orcid":"0000-0003-1009-6002","position":1,"is_corresponding":false},{"id":1592000,"name":"Che Ry Hong","orcid":null,"position":2,"is_corresponding":false},{"id":208336,"name":"Ji Won Lee","orcid":null,"position":3,"is_corresponding":false},{"id":1592004,"name":"Hyery Kim","orcid":null,"position":4,"is_corresponding":false},{"id":113253,"name":"Sang Hoon Song","orcid":null,"position":5,"is_corresponding":false},{"id":1589176,"name":"Kyung-Sang Yu","orcid":null,"position":6,"is_corresponding":false},{"id":1592008,"name":"In-Jin Jang","orcid":null,"position":7,"is_corresponding":false},{"id":1592009,"name":"June Dong Park","orcid":null,"position":8,"is_corresponding":false},{"id":1592010,"name":"Kyung Duk Park","orcid":null,"position":9,"is_corresponding":false},{"id":1592011,"name":"Hee Young Shin","orcid":null,"position":10,"is_corresponding":false},{"id":1592012,"name":"Joong-Gon Kim","orcid":null,"position":11,"is_corresponding":false},{"id":1592013,"name":"Hyo Seop Ahn","orcid":null,"position":12,"is_corresponding":false},{"id":1591994,"name":"Hee Young Ju","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Targeted busulfan and fludarabine-based conditioning for bone marrow transplantation in chronic granulomatous disease","abstract":"Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by impaired phagocytic function. Hematopoietic stem cell transplantation (HSCT) is a definitive cure for CGD; however, the use of HSCT is limited because of associated problems, including transplantation-related mortality and engraftment failure. We report a case of a patient with CGD who underwent successful HSCT following a targeted busulfan and fludarabine reduced-toxicity myeloablative conditioning. Intravenous busulfan was administered once daily for 4 consecutive days (days -8 to -5), and the target area under the curve was 75,000 ghr/L. Fludarabine (40 mg/m 2 ) was administered once daily for 6 consecutive days from days -8 to -3. Antithymocyte globulin (2.5 mg/kg/day) was administered from days -4 to -2. The patient underwent successful engraftment and did not have any severe toxicity related to the transplantation. Conditioning with a targeted busulfan and fludarabine regimen could provide a better outcome for HSCT in CGD, with close regulation of the busulfan dose.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28018447","pmcid":"PMC5177714","openalex_id":"https://openalex.org/W1266631045","authors":[],"funders":[{"funder_name":"Ministry of Food and Drug safety","grant_id":"11172MFDS288","title":null},{"funder_name":"Kyowa Hakko Kirin Korea","grant_id":"6020113640","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.e-cep.org/upload/pdf/kjped-59-S57.pdf","host_type":"journal"},{"url":"https://www.e-cep.org/upload/pdf/kjped-59-S57.pdf","host_type":"publisher"},{"url":"https://synapse.koreamed.org/pdf/10.3345/kjp.2016.59.11.S57","host_type":"publisher"},{"url":"https://synapse.koreamed.org/DOIx.php?id=10.3345/kjp.2016.59.11.S57","host_type":"publisher"},{"url":"http://kjp.or.kr/upload/pdf/kjped-59-S57.pdf","host_type":"publisher"},{"url":"https://doi.org/10.3345/kjp.2016.59.11.s57","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28018447","host_type":"repository"},{"url":"https://doaj.org/article/89bc90bf9f6e44038f087dff3fd3db43","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5177714","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5177714","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5177714?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neutrophil, Myeloperoxidase and Oxidative Mechanisms","Blood disorders and treatments","Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis"],"mesh_terms":[],"keywords":["Medicine","Busulfan","Fludarabine","Chronic granulomatous disease","Bone marrow transplantation","Transplantation","Bone marrow","Oncology","Internal medicine","Hematopoietic stem cell transplantation","Immunology","Chemotherapy","Cyclophosphamide","Transplantation Conditioning"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T01:24:11.298355Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}