{"doi":"10.3332/ecancer.2025.1845","title":"Association between tumour necrosis factor-a polymorphism and cervical cancer in Lagos State, Nigeria","abstract":"Background: The data on tumour necrosis factor-α (TNF-α) promoter gene polymorphism in the African population are relatively limited, especially in Nigerian women. Objectives: This study aimed to determine the prevalence and allele distribution of three TNF-α promoter gene SNPs loci - rs361525 (-238 G>A), rs1799964(-1031 T>C) and rs1800629 (-308 G>A) in women with cervical cancer (CC) and then evaluated the association between TNF-α SNPs and CC among women in Lagos, Nigeria. Methods: ≤ 0.05. Results: = 0.03) while the -308A>G A allele was also significantly associated with CC in HIV-positive women (OR = 1.33, 95%CI = 0.23-7.75). Conclusion: promoter gene loci, respectively, are more susceptible to CC. We were also able to show protective linkages for the minor allele of the three SNPs of interest suggesting the potential of TNF-a as a surrogate marker for CC screening in addition to human papillomavirus primary testing. Further studies are required to determine the association between host factors and TNF-a polymorphism to harness the diagnostic and therapeutic advantage these associations will provide in the management of CC.","journal":"ecancermedicalscience","year":2025,"id":543084,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9306,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1432482,"name":"Ifeoma Udenze","orcid":"0000-0002-1217-7167","position":1,"is_corresponding":false},{"id":879656,"name":"Adebola A. Adejimi","orcid":"0000-0003-3535-7344","position":2,"is_corresponding":false},{"id":769082,"name":"Obiefuna Ajie","orcid":"0000-0002-7827-5122","position":3,"is_corresponding":false},{"id":309363,"name":"Kehinde S. Okunade","orcid":"0000-0002-0957-7389","position":4,"is_corresponding":false},{"id":769081,"name":"Sarah John‐Olabode","orcid":"0000-0001-7130-9812","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:53:00.171379Z","pmid":"40259899","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}