{"doi":"10.3329/jbcps.v29i1.7167","title":"First Degree Relatives of Bangladeshi Prediabetic Subjects are at Increased Risk for Developing Glucose Intolerance","abstract":"<jats:p>Background: The racial variation in genetic susceptibility of Type2 diabetes mellitus is well established. The stages of impaired fasting glucose (IFG) and/or Impaired glucose tolerance (IGT) (collectively known as ‘prediabetic stages) are combined to be intermediate in the natural history of diabetes, but their genetic susceptibility are still a matter of investigation. Family study is the primary step to explore genetic susceptibility. In particular, there has been no study in Bangladesh related to genetics of prediabetes. Objectives: The present study aimed to explore the genetic susceptibility of prediabetes in Bangladeshi population by observing the clustering of dysglycemia in first degree relatives of prediabetes. Methodology: The study was designed as an experimental group comparison study. Newly detected prediabetic subjects (isolated IFG, IGT, IFG+IGT) were collected from BIRDEM OPD and reconfirmed by OGTT following WHO guidelines and sub grouped. Relatives of the prediabetes, up to first generation, were included as cases and termed as R-IFG (first degree relatives of IFG), R-IGT (first degree relatives of IGT), R-IFG-IGT (first degree relatives of IFG-IGT) corresponding to the subgroups of prediabetes. Each relative underwent an OGTT following the same guideline. Blood glucose was measured by glucose oxidase method. Results: Different types of prediabetic subjects (IFG, IGT, IFG+IGT) and their first degree relatives (R_IFG, R_IGT, R_IFG+IGT) were studied. Among 41 first degree relatives of IFG (R_IFG), 2 (4.9%) had IFG, 4 (9.8%) had IGT, 1 (2.4%) had combined IFG+IGT, 5 (12.5%) had T2 DM and 29 (70.7%) had normoglycemia. Among 116 first degree relatives of IGT (R_IGT) none (0.00%) had IFG, 15 (12.9%) had IGT, 2 (1.7%) had combined IFG+IGT, 22 (19%) had diabetes and 77 (66.4%) having absolutely normal OGTT reports. Among 76 first degree relatives of IFG+IGT (R_IFG+IGT), 2 (2.6%) had IFG, 4 (5.3%) had IGT, 1 (1.3%) had combined IFG+IGT, 19 (25%) had diabetes and 50 (65.8%) were normoglycemic. Conclusion: Clustering of pre-diabetes and diabetes is present in families of prediabetic subjects and they should be taken as a major target for primary prevention of these disorders. Key words: Prediabetes; IFG; IGT; IFG+IGT; First degree relatives; Glucose intolerance. DOI: 10.3329/jbsp.v29i1.7167J Bangladesh Coll Phys Surg 2011; 29:21-26</jats:p>","journal":"Journal of Bangladesh College of Physicians and Surgeons","year":1970,"id":46472,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":215506,"name":"MO Faruque","orcid":null,"position":1,"is_corresponding":false},{"id":215507,"name":"SH Khandker","orcid":null,"position":2,"is_corresponding":false},{"id":215508,"name":"ZA Latif","orcid":null,"position":3,"is_corresponding":false},{"id":215509,"name":"L Ali","orcid":null,"position":4,"is_corresponding":false},{"id":215505,"name":"SM Shefin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"First Degree Relatives of Bangladeshi Prediabetic Subjects are at Increased Risk for Developing Glucose Intolerance","abstract":"<jats:p>Background: The racial variation in genetic susceptibility of Type2 diabetes mellitus is well established. The stages of impaired fasting glucose (IFG) and/or Impaired glucose tolerance (IGT) (collectively known as ‘prediabetic stages) are combined to be intermediate in the natural history of diabetes, but their genetic susceptibility are still a matter of investigation. Family study is the primary step to explore genetic susceptibility. In particular, there has been no study in Bangladesh related to genetics of prediabetes. Objectives: The present study aimed to explore the genetic susceptibility of prediabetes in Bangladeshi population by observing the clustering of dysglycemia in first degree relatives of prediabetes. Methodology: The study was designed as an experimental group comparison study. Newly detected prediabetic subjects (isolated IFG, IGT, IFG+IGT) were collected from BIRDEM OPD and reconfirmed by OGTT following WHO guidelines and sub grouped. Relatives of the prediabetes, up to first generation, were included as cases and termed as R-IFG (first degree relatives of IFG), R-IGT (first degree relatives of IGT), R-IFG-IGT (first degree relatives of IFG-IGT) corresponding to the subgroups of prediabetes. Each relative underwent an OGTT following the same guideline. Blood glucose was measured by glucose oxidase method. Results: Different types of prediabetic subjects (IFG, IGT, IFG+IGT) and their first degree relatives (R_IFG, R_IGT, R_IFG+IGT) were studied. Among 41 first degree relatives of IFG (R_IFG), 2 (4.9%) had IFG, 4 (9.8%) had IGT, 1 (2.4%) had combined IFG+IGT, 5 (12.5%) had T2 DM and 29 (70.7%) had normoglycemia. Among 116 first degree relatives of IGT (R_IGT) none (0.00%) had IFG, 15 (12.9%) had IGT, 2 (1.7%) had combined IFG+IGT, 22 (19%) had diabetes and 77 (66.4%) having absolutely normal OGTT reports. Among 76 first degree relatives of IFG+IGT (R_IFG+IGT), 2 (2.6%) had IFG, 4 (5.3%) had IGT, 1 (1.3%) had combined IFG+IGT, 19 (25%) had diabetes and 50 (65.8%) were normoglycemic. Conclusion: Clustering of pre-diabetes and diabetes is present in families of prediabetic subjects and they should be taken as a major target for primary prevention of these disorders. Key words: Prediabetes; IFG; IGT; IFG+IGT; First degree relatives; Glucose intolerance. DOI: 10.3329/jbsp.v29i1.7167J Bangladesh Coll Phys Surg 2011; 29:21-26</jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24551422","pmcid":null,"openalex_id":"https://openalex.org/W2092344912","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.12018141,"influential_citations":0,"citation_trend":[{"year":2012,"count":1}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://www.banglajol.info/index.php/JBCPS/article/download/7167/5423","host_type":"journal"},{"url":"https://www.banglajol.info/index.php/JBCPS/article/download/7167/5423","host_type":"GOLD"},{"url":"https://www.banglajol.info/index.php/JBCPS/article/download/7167/5423","host_type":"publisher"},{"url":"https://doi.org/10.3329/jbcps.v29i1.7167","host_type":"journal"}],"fields_of_study":["Diabetes, Cardiovascular Risks, and Lipoproteins","Diet, Metabolism, and Disease","Diabetes and associated disorders","Medicine"],"mesh_terms":[],"keywords":["Impaired fasting glucose","Prediabetes","Impaired glucose tolerance","Medicine","First-degree relatives","Internal medicine","Diabetes mellitus","Endocrinology","Family history","Type 2 diabetes"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-10T05:18:56.653823Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}