{"doi":"10.33263/lianbs132.089","title":"Synthesis, Characterization, and Study of Anti-HPV Activity and Cell Cytotoxicity of Novel 1,3-Oxazole-4-Carbonitrile and 4-Sulfonylamide-5-Phenyl-1,3-Thiazole Derivatives in Vitro","abstract":"Five new 1,3-oxazole-4-carbonitrile and two 4-sulfonylamide-5-phenyl-1,3-thiazole derivatives were synthesized, and their activity against human papillomavirus (HPV) types 11, 16, and 18 was evaluated in C33-A cells in vitro. Bioassays showed that compounds 1 and 5-7 were inactive, while compounds 2 and 3 showed moderate activity against low-risk HPV11 and low cellular toxicity but were slightly selective. Only compound 4 (5-(4-benzenesulfonylpiperazine-1-sulfonyl)-2-phenyl-1,3-oxazole-4-carbonitrile) showed high activity against HPV11 similar to the reference drug (9-[2-phosphonomethoxy)ethyl]guanine) (EC50=3.68 and 1.77 μM, respectively), but had worse toxicity and selectivity However, the activity and selectivity of compound 4 exceeded that of the reference drug in concentration that caused 90% inhibition of virus replication, but was more toxic. Compound 4 also showed moderate activity against high-risk HPV16 and HPV18 in half maximal effective concentration. Thus, we have shown that compound 4 is a promising structure for in-depth study in order to develop a novel drug against HPV lesions.","journal":"Letters in Applied NanoBioScience","year":2024,"id":461839,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:04:16.410510Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}