{"doi":"10.32861/ijhms.92","title":"Untitled","abstract":"Plant parts play a crucial function to protect organisms from the toxic/carcinogenic effects of some compounds.The present study was carried out to investigate the protective effects of Graviola aqueous extract (GAE) against carbon tetrachloride (CCl 4 ) which induced hepatic injury in rats.Thirty male albino Wistar rats were divided into five groups: group I was used as controls, group II received daily GAE (300 mg/kg bw) alone orally for six weeks, group III received by IP injection CCl 4 in olive oil (50% V/V, 2 ml/kg bw), twice a week for two weeks, group IV, CCl 4 +GAE (curative group) injected CCl 4 twice a week for two weeks then concomitant with GAE (300 mg/kg BW) daily for next four weeks, and group V, GAE+CCl 4 (prophylactic group), received GAE, 300 mg/kg/day once daily orally four weeks, then concomitant with CCl 4 twice a week for next two weeks.The obtained results showed that the administration of CCl 4 caused hepatotoxicity as monitored by the significant (p≤0.05)increase in the levels of hepatic markers enzymes (alanine aminotransferase, ALT, aspartate aminotransferase, AST and alkaline phosphatase, ALP), total bilirubin (TB) and a decrease in hematological parameters such as white blood cell (WBC), red blood cell count (RBC), and blood platelet count (PLT).Also, our results showed that CCl 4 caused a significant (p≤0.05)increase in oxidative stress markers (malondialdehyde, MDA, reactive oxygen species, ROS, nitric oxide, NO), pro-inflammatory tumor necrosis factor-alpha (TNF-α,) level, and proapoptotic markers caspase-3, and B-cell lymphoma 2 (BCL-2)-like protein 4 (Bax).Furthermore, a significant (p≤0.05)decrease in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), reduced glutathione (GSH), and an antiapoptotic agent B-cell lymphoma 2 (Bcl-2) was observed in liver tissue.The detected CCl 4 effects were normalized by GAE administration, either a prophylactic or curative dose.Besides, GAE reduced the histopathological changes induced by CCl 4 .In conclusion, GAE was effective in both protecting and enhancing the liver deficits induced by CCl 4 through many potential mechanisms including antioxidant, antiinflammatory, antiapoptotic properties.Therefore, Graviola extracts up to 300 (mg/kg bw) could be considered a promising hepatoprotective supplement but more human clinical trials are also needed to validate the findings of the current research.","journal":"International Journal of Healthcare and Medical Sciences","year":2023,"id":406849,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:21:07.213041Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}