{"doi":"10.3233/ves-230300","title":"Vestibular-Oriented Research Meeting, June 25 – 29, 2023","abstract":"Vestibular inputs converge broadly with other sensory information across various brain functions.These multimodal contributions range from control of gaze and posture to higher-level mechanisms that mediate spatial orientation and motion perception.At the level of vestibulo-ocular refl ex (VOR), there is a close interaction between vestibular signals and proprioceptive inputs that encode the position of the neck.Neck proprioceptors provide information about the position of the head relative to the trunk and they can be used by the brain to optimize gaze control with respect to the head and body positions.The neural pathways that mediate these responses are not well understood, but physiological observations suggest that the brain can adapt to perturbations in vestibular function by using inputs from the neck.Here we studied the contribution of neck inputs to otolith-ocular function at different stages of recovery from vestibular loss.We used video-oculography (VOG)-based measurement of static ocular counter-roll (vOCR) determined 30 seconds after the dynamic tilt to assess otolith function.To elucidate a compensatory effect of neck proprioception, vOCR was measured with 30° static whole-body tilt (WBT) and head-on-body tilt (HBT).The vOCR with WBT is primarily driven by the otolith inputs, whereas with HBT there is also a neck contribution.Fifty-six subjects were recruited including patients with acute (9 days [mean]), subacute (61 days), and chronic (985 days) unilateral loss of vestibular function, as well as a group of healthy controls.The gain of vOCR on the lesion side was lower with WBT than with HBT in the acute and subacute groups but not in the chronic group or controls (HBT: acute: 0.11±0.01,subacute: 0.14±0.01,chronic: 0.13±0.02,healthy control: 0.17±0.01/WBT: acute: 0.08±0.01,subacute: 0.11±0.01,chronic: 0.13±0.02,healthy control: 0.18±0.01).The time course of vOCR response was affected as well with a reduced amplitude and slower response in the acute stage of vestibular loss.The vOCR with WBT, as opposed to HBT, could distinguish among the patient groups at various stages of vestibular loss.These fi ndings show a compensatory effect of neck proprioception that can enhance otolith-ocular function following vestibular loss and vOCR as a potential valuable clinical marker to track recovery following vestibular loss.","journal":"Journal of Vestibular Research","year":2023,"id":408957,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9412,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":2,"raw_metadata":null,"created_at":"2026-07-19T01:21:22.368387Z","pmid":"37355918","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}