{"doi":"10.3233/shti190246","title":"A Privacy-Preserving Infrastructure for Analyzing Personal Health Data in a Vertically Partitioned Scenario","abstract":"It is widely anticipated that the use and analysis of health-related big data will enable further understanding and improvements in human health and wellbeing. Here, we propose an innovative infrastructure, which supports secure and privacy-preserving analysis of personal health data from multiple providers with different governance policies. Our objective is to use this infrastructure to explore the relation between Type 2 Diabetes Mellitus status and healthcare costs. Our approach involves the use of distributed machine learning to analyze vertically partitioned data from the Maastricht Study, a prospective population-based cohort study, and data from the official statistics agency of the Netherlands, Statistics Netherlands (Centraal Bureau voor de Statistiek; CBS). This project seeks an optimal solution accounting for scientific, technical, and ethical/legal challenges. We describe these challenges, our progress towards addressing them in a practical use case, and a simulation experiment.","journal":"Studies in Health Technology and Informatics","year":2019,"id":662,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0505,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2019-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":6516,"name":"Wouters Birgit","orcid":null,"position":3,"is_corresponding":false},{"id":6518,"name":"Adekunle Onaopepo","orcid":null,"position":5,"is_corresponding":false},{"id":6519,"name":"van den Berg Bob","orcid":null,"position":6,"is_corresponding":false},{"id":6520,"name":"Mussmann Ole","orcid":null,"position":7,"is_corresponding":false},{"id":6521,"name":"Koster Annemarie","orcid":null,"position":8,"is_corresponding":false},{"id":6522,"name":"van der Kallen Carla","orcid":null,"position":9,"is_corresponding":false},{"id":6523,"name":"van Oppen Claudia","orcid":null,"position":10,"is_corresponding":false},{"id":14146,"name":"Jörg Tost","orcid":"0000-0002-2683-0817","position":11,"is_corresponding":false},{"id":6203,"name":"Chang Sun","orcid":"0000-0001-8325-8848","position":14,"is_corresponding":false},{"id":6527,"name":"Lianne Ippel","orcid":"0000-0001-8314-0305","position":15,"is_corresponding":false},{"id":6528,"name":"Johan van Soest","orcid":"0000-0003-2548-0330","position":16,"is_corresponding":false},{"id":6529,"name":"Birgit Wouters","orcid":null,"position":17,"is_corresponding":false},{"id":6530,"name":"Alexander Malic","orcid":"0000-0002-8394-3439","position":18,"is_corresponding":false},{"id":6532,"name":"Bob van den Berg","orcid":null,"position":20,"is_corresponding":false},{"id":6533,"name":"Ole Mussmann","orcid":null,"position":21,"is_corresponding":false},{"id":6534,"name":"Annemarie Koster","orcid":"0000-0003-1583-7391","position":22,"is_corresponding":false},{"id":6535,"name":"Carla Kallen","orcid":"0000-0003-1468-8793","position":23,"is_corresponding":false},{"id":6536,"name":"Claudia van Oppen","orcid":null,"position":24,"is_corresponding":false},{"id":6537,"name":"David Townend","orcid":"0000-0002-2409-0288","position":25,"is_corresponding":false},{"id":6538,"name":"André Dekker","orcid":"0000-0002-0422-7996","position":26,"is_corresponding":false},{"id":74,"name":"Michel J. Dumontier","orcid":"0000-0003-4727-9435","position":27,"is_corresponding":false}],"reference_count":0,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}