{"doi":"10.3233/rnn-2008-00437","title":"Cell adhesion molecules of the immunoglobulin superfamily in\t\t\t axonal regeneration and neural repair","abstract":"<jats:p>Cell adhesion molecules (CAMs) play important roles in cell-cell and\n\t\t\t cell-extracellular matrix interactions in both mature and developing nervous\n\t\t\t system. During development, they are involved in cell migration, axon guidance,\n\t\t\t target recognition, and synapse formation; while in the mature nervous system,\n\t\t\t they maintain synaptic connections, cell-cell contacts, and neuron-glial\n\t\t\t interactions. Injuries to the nervous systems break the stable state of the\n\t\t\t tissues and the repair of damaged tissues and regeneration of axons require the\n\t\t\t participation of CAMs both as adhesion molecules and as signal transduction\n\t\t\t molecules. One group of the well-studied CAMs in the nervous system is the\n\t\t\t immunoglobulin superfamily including L1 and neural cell adhesion molecule\n\t\t\t (NCAM). This review will be focussed on the involvement of L1, NCAM, and\n\t\t\t polysialylated NCAM in neural repair and axon regeneration after nerve injury\n\t\t\t and their potential applications in the treatment of CNS injury.</jats:p>","journal":"Restorative Neurology and Neuroscience","year":2008,"id":594073,"datarank":0.6814942173405006,"base_score":4.543294782270004,"endowment":4.543294782270004,"self_citation_contribution":0.6814942173405006,"citation_network_contribution":0.0,"self_endowment_contribution":0.6814942173405006,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":93,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1520615,"name":"John Yeh","orcid":null,"position":1,"is_corresponding":false},{"id":1223002,"name":"Peter M. Richardson","orcid":"0000-0002-6631-2459","position":2,"is_corresponding":false},{"id":1520616,"name":"Xuenong Bo","orcid":null,"position":3,"is_corresponding":false},{"id":414222,"name":"Yi Zhang","orcid":"0000-0002-7453-6188","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cell adhesion molecules of the immunoglobulin superfamily in\t\t\t axonal regeneration and neural repair","abstract":"<jats:p>Cell adhesion molecules (CAMs) play important roles in cell-cell and\n\t\t\t cell-extracellular matrix interactions in both mature and developing nervous\n\t\t\t system. During development, they are involved in cell migration, axon guidance,\n\t\t\t target recognition, and synapse formation; while in the mature nervous system,\n\t\t\t they maintain synaptic connections, cell-cell contacts, and neuron-glial\n\t\t\t interactions. Injuries to the nervous systems break the stable state of the\n\t\t\t tissues and the repair of damaged tissues and regeneration of axons require the\n\t\t\t participation of CAMs both as adhesion molecules and as signal transduction\n\t\t\t molecules. One group of the well-studied CAMs in the nervous system is the\n\t\t\t immunoglobulin superfamily including L1 and neural cell adhesion molecule\n\t\t\t (NCAM). This review will be focussed on the involvement of L1, NCAM, and\n\t\t\t polysialylated NCAM in neural repair and axon regeneration after nerve injury\n\t\t\t and their potential applications in the treatment of CNS injury.</jats:p>","is_dataset_classified":null,"base_score":4.543294782270004,"endowment":4.543294782270004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18820404","pmcid":null,"openalex_id":"https://openalex.org/W186337565","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":1,"fwci":3.3898,"citation_percentile":0.92905749,"influential_citations":0,"citation_trend":[{"year":2012,"count":15},{"year":2013,"count":8},{"year":2014,"count":4},{"year":2015,"count":4},{"year":2016,"count":4},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":9},{"year":2021,"count":4},{"year":2022,"count":5},{"year":2023,"count":3},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.3233/RNN-2008-00437","host_type":"publisher"},{"url":"https://doi.org/10.3233/rnn-2008-00437","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18820404","host_type":"repository"}],"fields_of_study":["Nerve injury and regeneration","Neurogenesis and neuroplasticity mechanisms","Axon Guidance and Neuronal Signaling"],"mesh_terms":["Animals","Central Nervous System","Humans","Immunoglobulins","Nerve Regeneration","Neuronal Plasticity","Spinal Cord Injuries","Genetic Therapy","Neural Cell Adhesion Molecules","Growth Cones","Neural Cell Adhesion Molecule L1"],"keywords":["Immunoglobulin superfamily","Neural cell adhesion molecule","Cell adhesion molecule","Nervous system","Regeneration (biology)","Axon","Extracellular matrix","Cell adhesion","Neuroscience","Biology","Neural cell","Axon guidance","Cell signaling","Cell biology","Central nervous system","Cell","Signal transduction","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T13:24:56.663861Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}