{"doi":"10.3233/npm-230157","title":"Clinical determinants of intestinal failure and death in preterm infants with surgical necrotizing enterocolitis","abstract":"OBJECTIVE: We sought to investigate the clinical determinants of intestinal failure and death in preterm infants with surgical NEC. METHODS: Retrospective comparison of clinical information between Group A = intestinal failure (Parenteral nutrition (PN) >90 days) and death and Group B = survivors and with PN dependence < 90 days in preterm infants with surgical NEC. RESULTS: Group A (n = 99/143) had a lower mean gestational age (26.4 weeks [SD3.5] vs. 29.4 [SD 3.5]; p = 0.013), lower birth weight (873 gm [SD 427g] vs. 1425 gm [894g]; p = <0.001), later age of NEC onset (22 days [SD20] vs. 16 days [SD 17]; p = 0.128), received surgery later (276 hours [SD 544] vs. 117 hours [SD 267]; p = 0.032), had cholestasis, received dopamine (80.6% vs. 58.5%; p = 0.010) more frequently and had longer postoperative ileus time (19.8 days [SD 15.4] vs. 11.8 days [SD 6.5]; p = <0.001) and reached full feeds later (93 days [SD 45] vs. 44 [SD 22]; p = <0.001) than Group B.On multivariate logistic regression, higher birth weight was associated with lower risk (OR 0.35, 95% CI 0.15-0.82; p = 0.016) of TPN > 90 days or death. Longer length of bowel resected (OR 1.76, 95% CI 1.02-3.02; p = 0.039) and longer postoperative ileus (OR 2.87, 95% CI 1.26-6.53; p = 0.011) were also independently associated with TPN >90days or death adjusted for gestational age and antenatal steroid treatment. CONCLUSION: In preterm infants with surgical NEC, clinical factors such as lower birth weight, longer bowel loss, and postoperative ileus days were significantly and independently associated with TPN >90 days or death.","journal":"Journal of Neonatal-Perinatal Medicine","year":2023,"id":378050,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7366,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1142444,"name":"P.M. Garg","orcid":null,"position":1,"is_corresponding":false},{"id":1142445,"name":"M.X. Denton","orcid":null,"position":2,"is_corresponding":false},{"id":317982,"name":"Rajesh Talluri","orcid":"0000-0002-6987-967X","position":3,"is_corresponding":false},{"id":965759,"name":"Md Abu Yusuf Ansari","orcid":"0000-0001-9076-9320","position":4,"is_corresponding":false},{"id":1113910,"name":"Robin Riddick","orcid":null,"position":5,"is_corresponding":false},{"id":1142446,"name":"M.M. Ostrander","orcid":null,"position":6,"is_corresponding":false},{"id":462742,"name":"Anna G. McDonald","orcid":null,"position":7,"is_corresponding":false},{"id":354286,"name":"Muralidhar H. Premkumar","orcid":"0000-0003-1401-9354","position":8,"is_corresponding":false},{"id":49897,"name":"William B. Hillegass","orcid":"0000-0001-6428-0564","position":9,"is_corresponding":false},{"id":1142447,"name":"P.P. Garg","orcid":null,"position":10,"is_corresponding":false},{"id":400551,"name":"Parvesh Mohan Garg","orcid":"0000-0001-5949-7304","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T01:16:44.708019Z","pmid":"38007677","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}