{"doi":"10.3233/jpd-230049","title":"40-Year Incidence of Early-Onset Parkinson’s Disease in Southeast Minnesota","abstract":"BACKGROUND: Parkinson's disease (PD) most commonly surfaces at middle age. An earlier onset is named early-onset Parkinson's disease (EOPD), but the exact definition is a matter of ongoing scientific debate. OBJECTIVE: To investigate 40-year EOPD incidence trends in a population-based cohort of parkinsonism in Olmsted County, Minnesota. METHODS: We used the Rochester Epidemiology Project (REP) to identify all incident EOPD cases in Olmsted County, 1976-2015. A movement-disorder specialist reviewed all cases to confirm the EOPD diagnosis. For EOPD definition, we used two age cut-offs: motor-symptom onset at or before 50 and 55 years. RESULTS: EOPD incidence was 1.43/100,000 person-years for ≤55 and 0.55/100,000 for ≤50 years. Men had a higher incidence in both groups [1.84 vs. 1.03 (p = 0.04); and 0.70 vs. 0.40 (p = 0.24), respectively]. EOPD incidence of patients with motor-symptom onset before age 55 increased from 1.02/100.000 person-year 1976-1985, to 1.32/100.000 person-year 2006-2015. A similar trend was observed when ≤50 years cut-off was used (0.28/100,000 person-years 1976-1985, to 0.59/100,000 person-year 2006-2015). However, negative binomial regression found no significant change in incidence per 10 years (RR = 1.04 and 1.24 in the two groups). Incidence was consistently higher in men than women. Median time from EOPD-symptom onset to death was shorter in the EOPD ≤55 group (21.9 years) compared to the EOPD ≤50 group (25.6 years). CONCLUSION: We observed an increased trend in the incidence of EOPD with both cut-off ages. Overall, incidence of EOPD was 1.43 (≤55) and 0.55 (≤50) cases per 100,000 person-years, higher in men.","journal":"Journal of Parkinson s Disease","year":2023,"id":351484,"datarank":0.5109219141545217,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.16553415020541482,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.16553415020541482,"corpus_percentile":62.27276243521312,"corpus_rank":4878,"citation_count":9,"citer_count":8,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5082,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":495411,"name":"Aidan F. Mullan","orcid":"0000-0001-8076-6935","position":1,"is_corresponding":false},{"id":270371,"name":"Pierpaolo Turcano","orcid":"0000-0002-3240-8348","position":2,"is_corresponding":false},{"id":429605,"name":"James H. Bower","orcid":null,"position":3,"is_corresponding":false},{"id":1096512,"name":"Capucine Piat","orcid":null,"position":4,"is_corresponding":false},{"id":706196,"name":"J. Eric Ahlskog","orcid":"0000-0002-3393-5561","position":5,"is_corresponding":false},{"id":259158,"name":"Rodolfo Savica","orcid":"0000-0002-2543-0627","position":6,"is_corresponding":false},{"id":782657,"name":"Emanuele Camerucci","orcid":"0000-0002-5510-9834","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T01:12:41.740237Z","pmid":"37522219","pmcid":"PMC10578273","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}