{"doi":"10.3233/jpd-230044","title":"Can Digital Mobility Assessment Enhance the Clinical Assessment of Disease Severity in Parkinson’s Disease?","abstract":"BACKGROUND: Real-world walking speed (RWS) measured using wearable devices has the potential to complement the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) for motor assessment in Parkinson's disease (PD). OBJECTIVE: Explore cross-sectional and longitudinal differences in RWS between PD and older adults (OAs), and whether RWS was related to motor disease severity cross-sectionally, and if MDS-UPDRS III was related to RWS, longitudinally. METHODS: 88 PD and 111 OA participants from ICICLE-GAIT (UK) were included. RWS was evaluated using an accelerometer at four time points. RWS was aggregated within walking bout (WB) duration thresholds. Between-group-comparisons in RWS between PD and OAs were conducted cross-sectionally, and longitudinally with mixed effects models (MEMs). Cross-sectional association between RWS and MDS-UPDRS III was explored using linear regression, and longitudinal association explored with MEMs. RESULTS: RWS was significantly lower in PD (1.04 m/s) in comparison to OAs (1.10 m/s) cross-sectionally. RWS significantly decreased over time for both cohorts and decline was more rapid in PD by 0.02 m/s per year. Significant negative relationship between RWS and the MDS-UPDRS III only existed at a specific WB threshold (30 to 60 s, β= - 3.94 points, p = 0.047). MDS-UPDRS III increased significantly by 1.84 points per year, which was not related to change in RWS. CONCLUSION: Digital mobility assessment of gait may add unique information to quantify disease progression remotely, but further validation in research and clinical settings is needed.","journal":"Journal of Parkinson s Disease","year":2023,"id":328353,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1049787,"name":"Rana Zia Ur Rehman","orcid":"0000-0002-4885-7455","position":1,"is_corresponding":false},{"id":1049788,"name":"Brook Galna","orcid":"0000-0002-5890-1894","position":2,"is_corresponding":false},{"id":1049789,"name":"Lisa Alcock","orcid":"0000-0002-8364-9803","position":3,"is_corresponding":false},{"id":1049790,"name":"Saverio Ranciati","orcid":"0000-0001-7880-9465","position":4,"is_corresponding":false},{"id":1049791,"name":"Luca Palmerini","orcid":"0000-0003-4758-662X","position":5,"is_corresponding":false},{"id":281739,"name":"Judith García‐Aymerich","orcid":"0000-0002-7097-4586","position":6,"is_corresponding":false},{"id":233016,"name":"Clint Hansen","orcid":"0000-0003-4813-3868","position":7,"is_corresponding":false},{"id":1049792,"name":"Eva Schaeffer","orcid":"0000-0002-0792-4383","position":8,"is_corresponding":false},{"id":17490,"name":"Daniela Berg","orcid":"0000-0001-5796-5442","position":9,"is_corresponding":false},{"id":233023,"name":"Walter Maetzler","orcid":"0000-0002-5945-4694","position":10,"is_corresponding":false},{"id":233020,"name":"Lynn Rochester","orcid":"0000-0001-5774-9272","position":11,"is_corresponding":false},{"id":1049793,"name":"Silvia Del Din","orcid":"0000-0003-1154-4751","position":12,"is_corresponding":false},{"id":841281,"name":"Alison J. Yarnall","orcid":"0000-0002-3126-9163","position":13,"is_corresponding":false},{"id":1049786,"name":"Cameron Kirk","orcid":"0000-0003-2508-5816","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T01:08:52.196069Z","pmid":"37545259","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}