{"doi":"10.3233/jpd-225105","title":"Levodopa Carbidopa Intestinal Gel in Advanced Parkinson’s Disease: DUOGLOBE Final 3-Year Results","abstract":"BACKGROUND: Levodopa-carbidopa intestinal gel (LCIG) improves motor and non-motor symptoms in patients with advanced Parkinson's disease (aPD). OBJECTIVE: To present the final 36-month efficacy and safety results from DUOGLOBE (DUOdopa/Duopa in Patients with Advanced Parkinson's Disease - a GLobal OBservational Study Evaluating Long-Term Effectiveness; NCT02611713). METHODS: DUOGLOBE was an international, prospective, long-term, real-world, observational study of patients with aPD initiating LCIG in routine clinical care. The primary endpoint was change in patient-reported \"Off\" time to Month 36. Safety was assessed by monitoring serious adverse events (SAEs). RESULTS: Significant improvements in \"Off\" time were maintained over 3 years (mean [SD]: -3.3 hours [3.7]; p < 0.001). There were significant improvements to Month 36 in total scores of the Unified Dyskinesia Rating Scale (-5.9 [23.7]; p = 0.044), Non-Motor Symptoms Scale (-14.3 [40.5]; p = 0.002), Parkinson's Disease Sleep Scale-2 (-5.8 [12.9]; p < 0.001), and Epworth Sleepiness Scale (-1.8 [6.0]; p = 0.008). Health-related quality of life and caregiver burden significantly improved through Months 24 and 30, respectively (Month 24, 8-item Parkinson's Disease Questionnaire Summary Index, -6.0 [22.5]; p = 0.006; Month 30, Modified Caregiver Strain Index, -2.3 [7.6]; p = 0.026). Safety was consistent with the well-established LCIG profile (SAEs: 54.9% of patients; discontinuations: 54.4%; discontinuations due to an adverse event: 27.2%). Of 106 study discontinuations, 32 patients (30.2%) continued LCIG outside the study. CONCLUSION: DUOGLOBE demonstrates real-world, long-term, reductions in motor and non-motor symptoms in patients with aPD treated with LCIG.","journal":"Journal of Parkinson s Disease","year":2023,"id":323370,"datarank":0.9448331507166357,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.39919522675767777,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.39919522675767777,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":21,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.93,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02611713"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":668264,"name":"Norbert Kovács","orcid":"0000-0002-7332-9240","position":1,"is_corresponding":false},{"id":668265,"name":"Francesco E. Pontieri","orcid":"0000-0002-8693-8432","position":2,"is_corresponding":false},{"id":469134,"name":"Jason Aldred","orcid":"0000-0001-7441-0967","position":3,"is_corresponding":false},{"id":252790,"name":"Paul Bourgeois","orcid":null,"position":4,"is_corresponding":false},{"id":668822,"name":"Thomas L. Davis","orcid":null,"position":5,"is_corresponding":false},{"id":524491,"name":"Esther Cubo","orcid":null,"position":6,"is_corresponding":false},{"id":668821,"name":"Marieta Anca‐Herschkovitsch","orcid":null,"position":7,"is_corresponding":false},{"id":668263,"name":"Robert Iansek","orcid":"0000-0001-8800-5209","position":8,"is_corresponding":false},{"id":668266,"name":"Mustafa Siddiqui","orcid":"0000-0003-4794-5119","position":9,"is_corresponding":false},{"id":668267,"name":"Mihaela Simu","orcid":"0000-0001-9676-1282","position":10,"is_corresponding":false},{"id":668268,"name":"Lars Bergmann","orcid":"0000-0002-8603-8549","position":11,"is_corresponding":false},{"id":1038664,"name":"Mayra Ballina","orcid":null,"position":12,"is_corresponding":false},{"id":668823,"name":"Pavnit Kukreja","orcid":null,"position":13,"is_corresponding":false},{"id":1038665,"name":"Omar Ladhani","orcid":null,"position":14,"is_corresponding":false},{"id":228504,"name":"Jia Jia","orcid":"0000-0001-6395-9487","position":15,"is_corresponding":false},{"id":230245,"name":"David G. Standaert","orcid":"0000-0003-2921-8348","position":16,"is_corresponding":false},{"id":656916,"name":"К. Ray Chaudhuri","orcid":"0000-0003-2815-0505","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T01:07:52.377944Z","pmid":"37302039","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}