{"doi":"10.3233/jpd-212979","title":"Outcomes Impacting Quality of Life in Advanced Parkinson’s Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel","abstract":"BACKGROUND: It is believed that motor symptoms, including dyskinesia, and non-motor symptoms impact health-related quality of life (HRQoL) in patients with Parkinson's disease (PD), and that improvements in these metrics are correlated. OBJECTIVE: Investigate the relationship between HRQoL and measures of PD severity and treatment efficacy, including motor and non-motor symptoms. METHODS: This was a planned investigation of an international, prospective, single-arm, post-marketing observational study of the long-term effectiveness of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Pearson correlation coefficients (PCC) were calculated for baseline and change from baseline at 12 months between HRQoL and motor and non-motor symptoms. RESULTS: A total of 195 patients were included. At baseline, HRQoL was moderately positively correlated with Activities of Daily Living (UPDRS II, PCC = 0.44), non-motor symptoms (0.48), and measures of sleep (0.50 and 0.40); all p < 0.001. After 12 months of treatment with LCIG, improvements in HRQoL were moderately positively correlated with improvement from baseline in non-motor symptoms (PCC = 0.42), sleep (0.54), and daytime sleepiness (0.40; all p < 0.001), and weakly correlated with improvement in dyskinesia signs and symptoms (PCC = 0.23; p = 0.011). Improvement in HRQoL was not correlated with improvements in OFF time or dyskinesia time. CONCLUSION: Both at baseline and for change from baseline at 12 months, HRQoL was correlated with baseline and change from baseline in dyskinesia, Activities of Daily Living, and non-motor symptoms, including sleep; but not with baseline or change in OFF time.","journal":"Journal of Parkinson s Disease","year":2021,"id":188788,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9377,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":668268,"name":"Lars Bergmann","orcid":"0000-0002-8603-8549","position":1,"is_corresponding":false},{"id":750666,"name":"Marieta Anca-Herschkovitsch","orcid":null,"position":2,"is_corresponding":false},{"id":524491,"name":"Esther Cubo","orcid":null,"position":3,"is_corresponding":false},{"id":668822,"name":"Thomas L. Davis","orcid":null,"position":4,"is_corresponding":false},{"id":142153,"name":"Robert Iansek","orcid":null,"position":5,"is_corresponding":false},{"id":750667,"name":"Mustafa S. Siddiqui","orcid":null,"position":6,"is_corresponding":false},{"id":668267,"name":"Mihaela Simu","orcid":"0000-0001-9676-1282","position":7,"is_corresponding":false},{"id":230245,"name":"David G. Standaert","orcid":"0000-0003-2921-8348","position":8,"is_corresponding":false},{"id":750668,"name":"K. Ray Chaudhuri","orcid":null,"position":9,"is_corresponding":false},{"id":252790,"name":"Paul Bourgeois","orcid":null,"position":10,"is_corresponding":false},{"id":750669,"name":"Tianming Gao","orcid":null,"position":11,"is_corresponding":false},{"id":668823,"name":"Pavnit Kukreja","orcid":null,"position":12,"is_corresponding":false},{"id":668265,"name":"Francesco E. Pontieri","orcid":"0000-0002-8693-8432","position":13,"is_corresponding":false},{"id":469134,"name":"Jason Aldred","orcid":"0000-0001-7441-0967","position":14,"is_corresponding":false},{"id":668264,"name":"Norbert Kovács","orcid":"0000-0002-7332-9240","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T23:49:10.350554Z","pmid":"34974438","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}