{"doi":"10.3233/jnd-180308","title":"Current Classification and Management of Inflammatory Myopathies","abstract":"<jats:p>Inflammatory disorders of the skeletal muscle include polymyositis (PM), dermatomyositis (DM), (immune mediated) necrotizing myopathy (NM), overlap syndrome with myositis (overlap myositis, OM) including anti-synthetase syndrome (ASS), and inclusion body myositis (IBM). Whereas DM occurs in children and adults, all other forms of myositis mostly develop in middle aged individuals. Apart from a slowly progressive, chronic disease course in IBM, patients with myositis typically present with a subacute onset of weakness of arms and legs, often associated with pain and clearly elevated creatine kinase in the serum. PM, DM and most patients with NM and OM usually respond to immunosuppressive therapy, whereas IBM is largely refractory to treatment. The diagnosis of myositis requires careful and combinatorial assessment of (1) clinical symptoms including pattern of weakness and paraclinical tests such as MRI of the muscle and electromyography (EMG), (2) broad analysis of auto-antibodies associated with myositis, and (3) detailed histopathological work-up of a skeletal muscle biopsy. This review provides a comprehensive overview of the current classification, diagnostic pathway, treatment regimen and pathomechanistic understanding of myositis.</jats:p>","journal":"Journal of Neuromuscular Diseases","year":2018,"id":688707,"datarank":0.8661827318316614,"base_score":5.7745515455444085,"endowment":5.7745515455444085,"self_citation_contribution":0.8661827318316614,"citation_network_contribution":0.0,"self_endowment_contribution":0.8661827318316614,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":321,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":14,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":853042,"name":"Jens Schmidt","orcid":"0000-0002-5589-2371","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Current Classification and Management of Inflammatory Myopathies","abstract":"<jats:p>Inflammatory disorders of the skeletal muscle include polymyositis (PM), dermatomyositis (DM), (immune mediated) necrotizing myopathy (NM), overlap syndrome with myositis (overlap myositis, OM) including anti-synthetase syndrome (ASS), and inclusion body myositis (IBM). Whereas DM occurs in children and adults, all other forms of myositis mostly develop in middle aged individuals. Apart from a slowly progressive, chronic disease course in IBM, patients with myositis typically present with a subacute onset of weakness of arms and legs, often associated with pain and clearly elevated creatine kinase in the serum. PM, DM and most patients with NM and OM usually respond to immunosuppressive therapy, whereas IBM is largely refractory to treatment. The diagnosis of myositis requires careful and combinatorial assessment of (1) clinical symptoms including pattern of weakness and paraclinical tests such as MRI of the muscle and electromyography (EMG), (2) broad analysis of auto-antibodies associated with myositis, and (3) detailed histopathological work-up of a skeletal muscle biopsy. This review provides a comprehensive overview of the current classification, diagnostic pathway, treatment regimen and pathomechanistic understanding of myositis.</jats:p>","is_dataset_classified":null,"base_score":5.7745515455444085,"endowment":5.7745515455444085,"datacite_reuse_total":14,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29865091","pmcid":"PMC6004913","openalex_id":"https://openalex.org/W2805713484","authors":[],"funders":[],"total_grants":0,"fwci":18.2947,"citation_percentile":0.99607237,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":4},{"year":2019,"count":14},{"year":2020,"count":49},{"year":2021,"count":55},{"year":2022,"count":50},{"year":2023,"count":50},{"year":2024,"count":37},{"year":2025,"count":39},{"year":2026,"count":21}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://content.iospress.com:443/download/journal-of-neuromuscular-diseases/jnd180308?id=journal-of-neuromuscular-diseases%2Fjnd180308","host_type":"journal"},{"url":"https://content.iospress.com:443/download/journal-of-neuromuscular-diseases/jnd180308?id=journal-of-neuromuscular-diseases%2Fjnd180308","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/pdf/10.3233/JND-180308","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.3233/JND-180308","host_type":"publisher"},{"url":"https://doi.org/10.3233/jnd-180308","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29865091","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6004913","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6004913","host_type":"repository"},{"url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/137429","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6004913","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6004913?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Inflammatory Myopathies and Dermatomyositis","Muscle Physiology and Disorders","Skin Diseases and Diabetes","Biopsy","Dermatomyositis","Disease Management","Electromyography","Humans","Magnetic Resonance Imaging","Muscle, Skeletal","Myositis","Myositis, Inclusion Body","Polymyositis"],"mesh_terms":["Biopsy","Dermatomyositis","Electromyography","Humans","Magnetic Resonance Imaging","Myositis","Polymyositis","Muscle, Skeletal","Myositis, Inclusion Body","Disease Management"],"keywords":["Myositis","Polymyositis","Inclusion body myositis","Medicine","Inflammatory myopathy","Muscle biopsy","Dermatomyositis","Myopathy","Overlap syndrome","Muscle weakness","Creatine kinase","Weakness","Proximal muscle weakness","Pathology","Dermatology","Biopsy","Internal medicine","Disease","Surgery","Skeletal muscle","Autoimmunity","neuroinflammation","immunosuppression","Muscle Inflammation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and 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